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Lipid Dynamics at Contact Sites Between the Endoplasmic Reticulum and Other Organelles

机译:内质网与其他细胞器之间的接触部位的脂质动态

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摘要

Phospholipids are synthesized primarily within the endoplasmic reticulum and are subsequently distributed to various subcellular membranes to maintain the unique lipid composition of specific organelles.As a result, in most cases, the steady-state localization of membrane phospholipids does not match their site of synthesis.This raises the question of how diverse lipid species reach their final membrane destinations and what molecular processes provide the energy to maintain the lipid gradients that exist between various membrane compartments.Recent studies have highlighted the role of inositol phospholipids in the nonvesicular transport of lipids at membrane contact sites.This review attempts to summarize our current understanding of these complex lipid dynamics and highlights their implications for defining future research directions.
机译:磷脂主要是在内质网内合成,随后将各种亚细胞膜分布以保持特定细胞器的独特脂质组合物。结果,在大多数情况下,膜磷脂的稳态定位与其合成位点不匹配。 这提出了多样化的脂质物种如何达到最终膜目的地以及哪些分子过程提供能量以维持各种膜隔室之间存在的脂质梯度。重复研究突出了肌醇磷脂在膜上的脂质脂质转运中的作用 联系站点。这方面审查试图总结我们目前对这些复杂的脂质动态的理解,并突出了它们对定义未来研究方向的影响。

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