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Antldiabetic Effect of Cleome droserlfolia Aerial Parts: Lipid Peroxidation-InducedIn Diabetic Rats

机译:鸡油菌空中部分的抗糖尿病作用:脂质过氧化诱导的糖尿病大鼠

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摘要

The present study aims to investigate the antidiabetic as well as the effect on lipid peroxidation of three different doses (50, 100, and 200 mg/kg) of Cleome droserifolia aerial parts methanolic extract in comparison with glibenclamide in alloxan-induced diabetic rats. Forty-two rats (35 diabetic and 1 normal) were included in this study. Oral administration of 100 and 200 mg/kg of the methanolic extract for 3 weeks significantly (P < 0.05) restored the blood glucose level, plasma malondialdehyde and urine sugar to near the physiological values whereas the effect of 50 mg/kg was not significant. Furthermore, from the HPLC chromatograms, we identified the presence of three flavonoids (quercetin, kaempferol, and isorhamnetin) together with three phenolic acids (sinapinic acid, ferulic acid and 4-coumaric acid) which may explain at least in part some of the antidiabetic and antioxidative properties observed in this study.
机译:本研究旨在研究与格列本脲相比,三种不同剂量(50、100和200 mg / kg)的Cleome droserifolia地上部分甲醇提取物的抗糖尿病药及其对脂质过氧化的作用,与格列本脲在四氧嘧啶诱导的糖尿病大鼠中进行比较。该研究包括42只大鼠(35只糖尿病大鼠和1只正常大鼠)。口服100和200 mg / kg的甲醇提取物持续3周(P <0.05)可将血糖水平,血浆丙二醛和尿糖恢复至接近生理值,而50 mg / kg的作用并不显着。此外,从HPLC色谱图中,我们鉴定出存在三种类黄酮(槲皮素,山奈酚和异鼠李素)以及三种酚酸(芥子酸,阿魏酸和4-香豆酸),这至少可以部分解释一些抗糖尿病药和这项研究中观察到的抗氧化性能。

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