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首页> 外文期刊>Autoimmune diseases >Role of hla-B alleles and clinical presentation of b27 negative spondyloarthritis patients from mumbai, Western India.
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Role of hla-B alleles and clinical presentation of b27 negative spondyloarthritis patients from mumbai, Western India.

机译：孟买孟买孟买B27阴性脊椎关节炎患者HLA-B等位基因及临床介绍的作用。

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摘要

Seronegative spondyloarthritis (SpA) are variably associated with HLA-B?27 antigen. HLA-B?27 negative SpA has also been reported from different parts of the world. There is paucity of data on this entity from Indian subcontinent. We studied 100 consecutively diagnosed HLA-B27 negative spondyloarthritis patients from a tertiary care center in India. Modified New York Criteria for ankylosing spondylitis (AS) and ESSG criteria for SpA were used for diagnosing patients. HLA-B?27 typing was done by an in-house PCR-SSP technique in SpA patients to exclude B?27 positive patients and PCR-SSOP technique was used to type 100 B?27negative SpA patients and 100 controls from the same ethnicity. Frequency of B?07 was significantly increased (B?07: % PF 54 versus 18; OR 5.348; 95% CI 2.808-10.186; P value 1.14E - 07), whereas frequency of B?40 was significantly decreased (B?40: % PF 17 versus 32; OR 0.435; 95% CI 0.222-0.850; P value 0.013) when compared with B?27 negative controls. Among 100 SpA patients, 47 were undifferentiated spondyloarthritis and 33 patients were reactive arthritis patients. 40% of the patients were suffering from polyarticular arthritis, 35% had pauciarticular arthritis with knee joint, hip joint, ankle joint, and SI joint involvement. We conclude that B?07 was significantly associated with B27 negative spondyloarthropathy from Western India and majority of B?27 negative patients were uSpA.
机译：血清腺性脊椎炎（SPA）是可变的与HLA-B？27抗原相关。 HLA-B？27个阴性水疗中心也从世界不同地区报道。来自印度次大陆的这个实体有缺乏数据。我们研究了100次诊断诊断的HLA-B27阴性脊椎关节炎，来自印度的三级护理中心。修改了鼻窦炎（AS）和SPA的ESSG标准的纽约标准用于诊断患者。 HLA-B？27型通过SPA患者的内部PCR-SSP技术进行，以排除B？27次阳性患者和PCR-SSOP技术用于100b？27个患者和来自同一种族的100个对照。 B？07的频率显着增加（B？07：％PF 54对18;或5.348; 95％CI 2.808-10.186; P值1.14E - 07），而B 20的频率显着降低（B？40 ：与B 2 27阴性对照相比，％PF 17与32的32个;或0.435; 95％CI 0.222-0.850; P值0.013）。在100名SPA患者中，47名是未分化的脊椎炎，33名患者是活性关节炎患者。 40％的患者患有多种子关节炎，35％的患有髌骨关节炎，髋关节，髋关节，踝关节和SI关节受累。我们得出结论，B？07与来自西部印度西部的B27阴性脊椎病明显相关，大多数B？27个阴性患者是USPA。

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  • 来源
    《Autoimmune diseases》 |2014年第1期|共1页
  • 作者

    Parasannanavar DJ;

  • 作者单位

    Microbiology and Immunology Division National Institute of Nutrition (ICMR) Jamai-Osmania;

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  • 正文语种 eng
  • 中图分类 内科学;
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