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首页> 外文期刊>Annual Review of Immunology >Rebooting Human Immunology
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Rebooting Human Immunology

机译：重新启动人类免疫学

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Recent progress in both conceptual and technological approaches to human immunology have rejuvenated a field that has long been in the shadow of the inbred mouse model. This is a healthy development both for the clinical relevance of immunology and for the fact that it is a way to gain access to the wealth of phenomenology in the many human diseases that involve the immune system. This is where we are likely to discover new immunological mechanisms and principals, especially those involving genetic heterogeneity or environmental influences that are difficult to model effectively in inbred mice. We also suggest that there are likely to be novel immunological mechanisms in long-lived, less fecund mammals such as human beings since they must remain healthy far longer than short-lived rodents in order for the species to survive.
机译：最近对人类免疫学的概念和技术方法的进展已经恢复活力，这是一个长期以来一直在近交小鼠模型的阴影的领域。 这是一种健康的发展，用于免疫学的临床相关性以及它是一种方法，即它是在许多人类疾病中获得涉及免疫系统的许多人类疾病的丰富的方法。 这是我们可能发现新的免疫机制和校长的地方，特别是那些涉及遗传异质性或环境影响的人，这些影响难以在近交小鼠中有效地模拟。 我们还表明，长期存在的免疫机制可能是一种新的免疫机制，诸如人类，因为人类必须保持比短期啮齿动物更健康，以便物种生存。

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