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首页> 外文期刊>Advances in clinical chemistry >Clinical relevance of BNP measurement in the follow-up of patients with chronic heart failure.
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Clinical relevance of BNP measurement in the follow-up of patients with chronic heart failure.

机译：BNP测定在慢性心力衰竭患者随访中的临床意义。

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摘要

The measurement of circulating brain natriuretic peptide (BNP) and its related peptide, the N-terminal fragment of proBNP (NT-proBNP), have a high degree of diagnostic accuracy and clinical relevance both in acute and chronic heart failure (HF). However, the role of measurement of BNP/NT-proBNP in the follow-up of treated HF patients is still debated. In this chapter, authors have studied the clinical impact of B-type natriuretic peptide assay in the follow-up of patients with heart failure, and, in particular, the possible role of the measurement of its circulating levels in guiding the treatment. A relatively small number of randomized studies were designed to specifically evaluate the clinical use of BNP/NT-proBNP assay in monitoring and tailoring the medical therapy in HF patients. A meta-analysis of results reported in these studies indicate that the inefficacy to improve the mortality rate of the peptide-guided compared to the control group found in some studies, may depend on to the inability of current therapeutic strategies to modify prognosis, especially in the elderly subset of patients, who are characterized by more advanced disease and comorbidities. Further prospective and randomized clinical studies are necessary to definitively demonstrate whether BNP/ NT-proBNP-guided therapy is able to significantly improve the outcome of patients with HF.
机译：循环脑利钠肽（BNP）及其相关肽，proBNP的N端片段（NT-proBNP）的测量在急性和慢性心力衰竭（HF）中具有高度的诊断准确性和临床意义。然而，BNP / NT-proBNP的测量在治疗HF患者的随访中的作用仍存在争议。在本章中，作者研究了B型利钠肽测定对心力衰竭患者的随访的临床影响，尤其是测量其循环水平在指导治疗中的可能作用。设计了相对较少的随机研究，以专门评估BNP / NT-proBNP分析在监测和调整HF患者药物治疗中的临床应用。对这些研究报告的结果进行的荟萃分析表明，与某些研究中的对照组相比，提高肽指导的死亡率的无效性可能取决于当前治疗策略无法改变预后，尤其是对于以较晚期疾病和合并症为特征的老年患者。有必要进行进一步的前瞻性和随机临床研究，以明确证明BNP / NT-proBNP指导的治疗是否能够显着改善HF患者的预后。

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