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首页> 外文期刊>International journal of immunogenetics >Impact and production of Non‐HLA‐specific antibodies in solid organ transplantation
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Impact and production of Non‐HLA‐specific antibodies in solid organ transplantation

机译：固体器官移植中非HLA特异性抗体的影响和生产

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Abstract Organ transplantation is an effective way to treat end‐stage organ disease. Extending the graft survival is one of the major goals in the modern era of organ transplantation. However, long‐term graft survival has not significantly improved in recent years despite the improvement of patient management and advancement of immunosuppression regimen. Antibody‐mediated rejection is a major obstacle for long‐term graft survival. Donor human leucocyte antigen (HLA)‐specific antibodies were initially identified as a major cause for antibody‐mediated rejection. Recently, with the development of solid‐phase‐based assay reagents, the contribution of non‐HLA antibodies in organ transplantation starts to be appreciated. Here, we review the role of most studied non‐HLA antibodies, including angiotensin II type 1 receptor (AT 1 R), K‐α‐tubulin and vimentin antibodies, in the solid organ transplant, and discuss the possible mechanism by which these antibodies are stimulated.
机译：摘要器官移植是治疗终级器官疾病的有效方法。延长移植物生存是当前时代的器官移植的主要目标之一。然而，尽管患者管理和推进免疫抑制方案，但近年来，长期移植存活率近年来并没有显着改善。抗体介导的排斥是长期移植存活的主要障碍。最初将供体人白细胞抗原（HLA）特异性抗体鉴定为抗体介导的排斥的主要原因。最近，随着基于固相的测定试剂的发展，在器官移植中的非HLA抗体的贡献开始理解。在这里，我们审查了大多数研究的非HLA抗体的作用，包括血管紧张素II型1受体（在1 r），K-α-微管蛋白和平节抗体，在固体器官移植中，并讨论这些抗体的可能机制受到刺激。

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