The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes

Majorczyk Edyta; Wisniewski Andrzej; Zon-Giebel Aleksandra; Chlebicki Arkadiusz; Wiland Piotr; Kusnierczyk Piotr

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The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes

机译：LILRB1但不是LILRA3基因多态性在脊柱神经病理学免疫病理学中的影响 - 一种与KIR基因平行的

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摘要

LILR and KIR receptors recognize HLA-B27 and may influence immune response in ankylosing spondylitis (AS) development. Purpose of the study was to analyse LILRB1/LILRA3 polymorphisms in AS. We observed a possible protective effect of the T allele of LILRB1 rs1061680:T>C and no association with insertion/deletion polymorphisms of LILRA3 with AS.

机译：LILR和KIR受体识别HLA-B27，并可能影响强直性脊柱炎（AS）发育中的免疫应答。该研究的目的是分析LILRB1 / LILRA3多态性。我们观察了LILRB1 RS1061680：T> C的T等位基因的可能保护作用，并且与LILRA3的插入/缺失多态性无关。

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来源
《International journal of immunogenetics》 |2019年第3期|共6页
作者
Majorczyk Edyta; Wisniewski Andrzej; Zon-Giebel Aleksandra; Chlebicki Arkadiusz; Wiland Piotr; Kusnierczyk Piotr;
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作者单位

Polish Acad Sci Ludwik Hirszfeld Inst Immunol &

Expt Therapy Dept Clin Immunol Wroclaw Poland;

Polish Acad Sci Ludwik Hirszfeld Inst Immunol &

Expt Therapy Dept Clin Immunol Wroclaw Poland;

Silesian Ctr Rheumatol Rehabil &

Disabil Prevent Ustron Poland;

Wroclaw Med Univ Fac Med Dept &

Clin Rheumatol &

Internal Med Wroclaw Poland;

Wroclaw Med Univ Fac Med Dept &

Clin Rheumatol &

Internal Med Wroclaw Poland;

Polish Acad Sci Ludwik Hirszfeld Inst Immunol &

Expt Therapy Dept Clin Immunol Wroclaw Poland;

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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
ankylosing spondylitis; genetics; HLA-B27; KIR; LILR;

机译：强直性脊柱炎;遗传学;HLA-B27;KIR;LILR;

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专利

1. The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes [J] . Majorczyk Edyta, Wisniewski Andrzej, Zon-Giebel Aleksandra, International journal of immunogenetics . 2019,第3期

机译：LILRB1但不是LILRA3基因多态性在脊柱神经病理学免疫病理学中的影响 - 一种与KIR基因平行的
2. Possible Role of HLA-G, LILRB1 and KIR2DL4 Gene Polymorphisms in Spontaneous Miscarriage [J] . Nowak Izabela, Malinowski Andrzej, Barcz Ewa, Archivum immunologiae et therapiae experimentalis . 2016,第6期

机译：HLA-G，LILRB1和KIR2DL4基因多态性在自然流产中的可能作用
3. Genetic polymorphisms and expression of HLA-G and its receptors, KIR2DL4 and LILRB1, in non-small cell lung cancer [J] . Wisniewski A., Kowal A., Wyrodek E., Tissue antigens. . 2015,第6期

机译：非小细胞肺癌的HLA-G及其受体KIR2DL4和LILRB1的遗传多态性及其表达
4. Genes and immunopathology [C] . Falk Symposium . 2004

机译：基因和免疫病理学
5. Genetic polymorphisms in disease susceptibility: Gene-gene and gene-environment interactions. [D] . Johnson, Jeremy David. 2007

机译：疾病易感性的遗传多态性：基因-基因和基因-环境相互作用。
6. Possible Role of HLA-G LILRB1 and KIR2DL4 Gene Polymorphisms in Spontaneous Miscarriage [O] . Izabela Nowak, Andrzej Malinowski, Ewa Barcz, -1

机译：HLA-GLILRB1和KIR2DL4基因多态性在自然流产中的可能作用
7. Structural Differences in KIR3DL1 and LILRB1 Interaction with HLA-B and the Loading Peptide Polymorphisms: In Silico Evidences [O] . Alba Grifoni, Atanas Patronov, Carla Montesano, 2015

机译：Kir3DL1和LILRB1与HLA-B相互作用的结构差异和装载肽多态性：在硅证像中

The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes

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