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首页> 外文期刊>International journal of immunogenetics >Association between the CD14?260C>T gene polymorphism and susceptibility to myocardial infarction: Evidence from case?control studies
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Association between the CD14?260C>T gene polymorphism and susceptibility to myocardial infarction: Evidence from case?control studies

机译：CD14-260C> T基因多态性与心肌梗死的易感性之间的关联：来自案例的证据？对照研究

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Abstract Numerous published studies have investigated the relationship between the CD14?260CT (rs2569190) polymorphism and the risk of myocardial infarction (MI). However, the results are still conflicting and inconclusive. Potentially eligible published articles were searched in four databases including PubMed, Web of Science, EMBASE and Chinese Biomedical Database (CBM). The odds ratio (OR) with its 95% confidence interval (CI) was used to estimate the strength of the associations. Thirteen papers including 17 case–control studies were included, reporting a total of 6,443 MI patients and 6,315 controls. A significant increase in overall MI susceptibility was identified in the homozygote model. In the subgroup analysis, with respect to the type of MI, a significantly increasing acute MI susceptibility was found in the homozygote model. In the subgroup analysis for ethnicity, a significant increased susceptibility was found in Asian populations in allele, homozygote, recessive and dominant models. However, no significant association was found among Caucasian populations. In conclusion, there may be a moderate association between the CD14?260CT polymorphism and acute MI susceptibility. This association may be different between ethnicities with the CD14?260CT polymorphism being a risk factor for myocardial infarction in Asian populations.
机译：摘要众多公布的研究研究了CD14？260c＆ t（rs2569190）多态性与心肌梗塞的风险（mi）之间的关系。但是，结果仍然相互矛盾，不确定。在四个数据库中搜索潜在的符合条件的公布文章，包括PubMed，Semotical，Embase和中国生物医学数据库（CBM）。使用其95％置信区间（CI）的差距（或）估计协会的强度。包括17项病例对照研究的十三篇论文包括，报告总共6,443例MI患者和6,315名对照。在Homozygote模型中鉴定了整体MI易感性的显着增加。在亚组分析中，关于MI的类型，在Homozygote模型中发现了显着增加的急性Mi易感性。在种族的亚组分析中，亚洲群体中的亚洲群体中发现了显着增加的易感性，纯合子，隐性和主导模型。然而，在白种人人群中没有发现任何重大关联。总之，CD14Δ260c＆ t多态性和急性mi易感性之间可能存在中度关联。这种关联可能与CD14？260c＆ t多态性在亚洲群体中是心肌梗塞的危险因素。

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