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首页> 外文期刊>Eating and weight disorders: EWD >Directly measured free 25-hydroxy vitamin D levels show no evidence of vitamin D deficiency in young Swedish women with anorexia nervosa
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Directly measured free 25-hydroxy vitamin D levels show no evidence of vitamin D deficiency in young Swedish women with anorexia nervosa

机译：直接测量的免费25-羟基维生素D水平显示没有厌食症患者的维生素D缺乏缺乏症的证据

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Abstract Purpose Anorexia nervosa (AN) is an eating disorder characterized by low fat mass complicated by osteoporosis. The role of circulating vitamin D in the development of bone loss in AN is unclear. Fat mass is known to be inversely associated with vitamin D levels measured as serum levels of total, protein-bound 25-hydroxyvitamin D, but the importance of directly measured, free levels of 25(OH)D has not been determined in AN. The aim of this study was to investigate vitamin D status, as assessed by serum concentrations of total and free serum 25(OH)D in patients with AN and healthy controls. Methods In female AN patients ( n ?=?20), and healthy female controls ( n ?=?78), total 25(OH)D was measured by LC–MS/MS, and free 25(OH)D with ELISA. In patients with AN bone mineral density (BMD) was determined with DEXA. Results There were no differences between patients and controls in total or free S-25(OH)D levels (80?±?31 vs 72?±?18?nmol/L, and 6.5?±?2.5 vs 5.6?±?1.8?pg/ml, respectively), and no association to BMD was found. In the entire group of patients and controls, both vitamin D parameters correlated with BMI, leptin, and PTH. Conclusions The current study did not demonstrate a vitamin D deficiency in patients with AN and our data does not support vitamin D deficiency as a contributing factor to bone loss in AN. Instead, we observed a trend toward higher vitamin D levels in AN subjects compared to controls. Measurement of free vitamin D levels did not contribute to additional information.
机译：摘要目的厌食症（AN）是一种饮食障碍，其特征在于骨质疏松症的低脂肪量。循环维生素D在肝脏损失发展中的作用尚不清楚。已知脂肪质量与作为总量的血清水平测量的维生素D水平与总，蛋白质结合的25-羟基vitamin d相反，但直接测量的重要性，25（OH）d的重要性尚未确定。本研究的目的是研究维生素D状态，如血清浓度的血清浓度和健康对照的患者中的血清浓度评估。雌性患者（n？=α2）和健康的雌性对照（n？=Δ78），通过LC-MS / MS测量总25（OH），并使用ELISA自由25（OH）D.在患有骨矿物密度（BMD）的患者中，用DEXA测定。结果患者与游离的患者或游离S-25（OH）D水平没有差异（80？±31 Vs 72？±18？Nmol / L和6.5？±2.5​​ Vs 5.6？±？1.8分别存在pg / ml，未发现与BMD的关联。在整组患者和对照组中，维生素D参数均与BMI，瘦素和PTH相关。结论目前的研究没有证明患者的维生素D缺乏症，我们的数据不支持维生素D缺乏，因为骨质损失的贡献因素。相反，与对照相比，我们观察了对受试者更高的维生素D水平的趋势。自由维生素D水平的测量没有贡献其他信息。

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