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p13 protects against Parkinson's disease

机译:P13保护帕金森病

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摘要

Mitochondrial dysfunction is thought to contribute to Parkinson's disease progression, and factors that can overcome mitochondrial defects could potentially be used to combat the disease and prevent neuronal death. In this issue, Inoue et al report that reduction of p13, a mitochondrial protein that inhibits complex I assembly, rescues the cellular and behavioral defects of Parkinson's disease models. This work suggests that stabilizing the mitochondrial electron transport chain may be beneficial in the context of Parkinson's disease.
机译:被认为有助于帕金森氏病进展的线粒体功能障碍,并且可以克服线粒体缺陷的因素可能用于打击这种疾病并预防神经元死亡。 在这个问题中,Inoue等报告称P13的减少,一种抑制我组装的线粒体蛋白,拯救了帕金森病模型的细胞和行为缺陷。 这项工作表明,在帕金森病的背景下稳定线粒体电子传输链可能是有益的。

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