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首页> 外文期刊>Biochimica et biophysica acta. Reviews on cancer >Challenges and prospects of immunotherapy as cancer treatment
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Challenges and prospects of immunotherapy as cancer treatment

机译：免疫疗法作为癌症治疗的挑战和前景

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The concept of cancer immunotherapy stems from the proposed function of the immune system, called immunosurveillance, to protect against growing tumors. Due to genetic aberrations, tumor cells display an altered repertoire of MHC-associated peptides that can lead to the activation of immune cells able to eliminate the transformed cells. In some instances, under the pressure of the immune system, both the tumor and its microenvironment are shaped and immune-resistant tumor variants are selected initiating the process of cancer immunoediting. This can impair not only host-generated immunosurveillance, but also attempts to harness the immune response for therapeutic purposes, namely immunotherapy. Rather than being an exhaustive review of the different approaches of cancer immunotherapy, the focus of this review is to provide the reader with future challenges of the field by proposing 'second generation' immunotherapy approaches that take into account immumosubversive mechanisms adopted by tumor cells. After an introduction on the process of immunosurveillance and immunoescape we will analyze why current immunotherapy approaches have not fulfilled their promise and will finish by summarizing what are the challenges for future approaches. (c) 2007 Elsevier B.V. All rights reserved.
机译：癌症免疫疗法的概念源于所提议的免疫系统功能，称为免疫监视，可防止肿瘤生长。由于遗传畸变，肿瘤细胞显示出与MHC相关的肽的变化，这可能导致能够消除转化细胞的免疫细胞活化。在某些情况下，在免疫系统的压力下，肿瘤及其微环境都被成形，并选择了具有免疫抵抗力的肿瘤变异体，从而启动了癌症免疫编辑的过程。这不仅会损害宿主产生的免疫监视，而且还会尝试利用免疫应答进行治疗，即免疫治疗。而不是详尽地综述癌症免疫治疗的不同方法，本综述的重点是通过提出“第二代”免疫治疗方法来为读者提供该领域的未来挑战，该方法考虑了肿瘤细胞采用的免疫破坏机制。在介绍了免疫监视和免疫逃逸的过程之后，我们将分析为什么当前的免疫治疗方法没有实现其诺言，并通过总结未来方法的挑战来结束。 （c）2007 Elsevier B.V.保留所有权利。

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