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首页> 外文期刊>European heart journal cardiovascular Imaging >MITRA-FR vs. COAPT: lessons from two trials with diametrically opposed results
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MITRA-FR vs. COAPT: lessons from two trials with diametrically opposed results

机译：Mitra-FR与COAPT：来自两项试验的课程，具有截然基础的结果

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摘要

Percutaneous mitral valve repair using the MitraClip device has been proposed to correct secondary mitral regurgitation (MR). Recently, the results of two randomized controlled trials, that is MITRA-FR (Percutaneous Repair with the MitraClip Device for Severe Functional/Secondary Mitral Regurgitation) and COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation), assessing the efficacy and safety of MitraClip in patients with systolic heart failure and severe secondary MR were published. A priori, these two trials targeted the same patient populations with the same disease using the same device but the results of these trials were diametrically opposed, MITRA-FR being neutral and COAPT being highly positive with respect to efficacy of the MitraClip procedure. The objectives of this viewpoint are: (i) to highlight not only the similarities but also the differences between MITRA-FR and COAPT, which may explain the strikingly different results and conclusions between these two trials and (ii) to derive from these results, implications with regards to the application of the MitraClip procedure in clinical practice.
机译：已经提出了使用MITRACLIP器件的经皮二尖瓣修复以纠正次级二尖瓣反流（MR）。最近，两种随机对照试验的结果，即Mitra-Fr（用MitroaClip装置经皮修复，用于严重功能/二次二尖瓣反流性的COAPT（心血管结果对心力衰竭患者的麦克拉利患者进行功能二尖瓣反流的疗效评估） ，评估麦克拉脂对收缩性心力衰竭患者的疗效和安全性和严重的中学生发表。先验，这两项试验靶向了使用相同装置的相同患者的患者群，但这些试验的结果是径向相对的，MITRA-FR是中性的，并且相对于MITRACLIP程序的功效具有高度阳性的阳性。这个观点的目标是：（i）不仅要突出相似性，而且突出了Mitra-Fr和CoApt之间的差异，这可以解释这两项试验和（ii）之间的显着不同的结果和结论，以得出这些结果，关于在临床实践中的应用程序在临床实践中的应用。

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