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首页> 外文期刊>BJOG: an international journal of obstetrics and gynaecology >Evidence of early first-trimester growth restriction in pregnancies that subsequently end in miscarriage.
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Evidence of early first-trimester growth restriction in pregnancies that subsequently end in miscarriage.

机译：妊娠早期妊娠早期生长受限的证据，随后以流产结束。

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OBJECTIVES: To examine whether viable early pregnancies that subsequently end in miscarriage exhibit evidence of first-trimester growth restriction. DESIGN: Prospective cohort study. SETTING: Early pregnancy unit (EPU) of a teaching hospital. POPULATION: Women attending EPU between 5 and 10 weeks of gestation. METHODS: Women with spontaneously conceived intrauterine, viable singleton pregnancies with certain last menstrual period and regular cycles were included. The deviation between the observed and expected crown-rump length (CRL) for gestation was calculated and expressed as a z score. Pregnancies were followed up until the 11-14 week scan, and the deviation between those that remained viable and miscarried subsequently was calculated. MAIN OUTCOME MEASURES: Viability at 11-14 week scan. RESULTS: Over 6 months, 316 women met the inclusion criteria. Twenty-four (7.4%) women were excluded. Of the remaining 292, the pregnancy remained viable in 251 (86%) and 41 (14%) suffered a miscarriage. At the first transvaginal ultrasound, the z score of the mean measured CRL for pregnancies that remained viable was -0.82, SD 1.46, while in pregnancies that subsequently miscarried the z score was -2.42 and the CRL was significantly smaller, SD 1.31 (P < 0.0001). In the latter group, the initial CRL was below the expected mean for gestational age in all women, while in 61% (25/41), the CRL was at least 2 SDs below the expected mean. CONCLUSIONS: CRL was significantly smaller in pregnancies that subsequently ended in miscarriage. This suggests that early first-trimester growth restriction is associated with subsequent intrauterine death.
机译：目的：检查可行的早孕并随后以流产结束，是否显示出孕早期生长受限的证据。设计：前瞻性队列研究。地点：教学医院的早孕病房（EPU）。人口：在妊娠5到10周之间参加EPU的妇女。方法：包括自发性宫内节育，可行的单胎妊娠，一定的末次月经周期和定期周期的妇女。计算观察到的和预期的妊娠臀围长度（CRL）之间的偏差，并表示为z得分。怀孕一直进行到11-14周扫描为止，然后计算出仍然存活和流产的孕妇之间的偏差。主要观察指标：11-14周扫描时生存力。结果：超过6个月，有316名妇女符合纳入标准。排除了二十四名（7.4％）妇女。在其余的292人中，有251人（86％）能够继续怀孕，流产的人中有41人（14％）能够继续怀孕。在第一次经阴道超声检查中，存活的孕妇的平均CRL的z得分为-0.82，SD为1.46，随后流产的孕妇的Z得分为-2.42，CRL明显较小，SD为1.31（P < 0.0001）。在后一组中，所有女性的初始CRL均低于胎龄的预期平均值，而在61％（25/41）中，CRL低于预期均值至少2 SD。结论：怀孕中的CRL明显较小，随后以流产告终。这表明早孕期早期生长受限与随后的子宫内死亡有关。

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