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Behavioral profiling of multiple pairs of rats selectively bred for high and low alcohol intake using the MCSF test

机译：使用MCSF测试为高和低酒精摄入量选择性繁殖的多对大鼠的行为分析

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Genetic aspects of alcoholism have been modeled using rats selectively bred for extremes of alcohol preference and voluntary alcohol intake. These lines show similar alcohol drinking phenotypes but have different genetic and environmental backgrounds and may therefore display diverse behavioral traits as seen in human alcoholics. The multivariate concentric square fielda￠ (MCSF) test is designed to provoke exploration and behaviors associated with risk assessment, risk taking and shelter seeking in a novel environment. The aim was to use the MCSF to characterize behavioral profiles in rat lines from selective breeding programs in the United States (P/NP, HAD1/LAD1, HAD2/LAD2), Italy (sP/sNP) and Finland (AA/ANA). The open field and elevated plus maze tests were used as reference tests. There were substantial differences within some of the pairs of selectively bred rat lines as well as between all alcohol-preferring rats. The most pronounced differences within the pairs of lines were between AA and ANA rats and between sP and sNP rats followed by intermediate differences between P and NP rats and minor differences comparing HAD and LAD rats. Among all preferring lines, P, HAD1 and HAD2 rats shared similar behavioral profiles, while AA and sP rats were quite different from each other and the others. No single trait appeared to form a common 'pathway' associated with a high alcohol drinking phenotype among all of the alcohol-preferring lines of rats. The marked behavioral differences found in the different alcohol-preferring lines may mimic the heterogeneity observed among human alcoholic subtypes.
机译：酒精中毒的遗传方面已使用选择性饲养的大鼠进行建模，以研究其对酒精的偏爱和自愿饮酒的极端情况。这些品系显示出相似的饮酒表型，但具有不同的遗传和环境背景，因此可能显示出人类饮酒者所表现出的多种行为特征。多元同心平方场检验（MCSF）旨在激发与探索和行为相关的风险评估，风险承担和寻求庇护的环境。目的是使用MCSF来表征美国（P / NP，HAD1 / LAD1，HAD2 / LAD2），意大利（sP / sNP）和芬兰（AA / ANA）的选择性育种计划中大鼠品系的行为特征。野外测试和高架迷宫测试被用作参考测试。在某些成对选育的大鼠品系中以及所有偏好酒精的大鼠之间都存在实质性差异。成对品系之间最明显的差异是AA和ANA大鼠之间以及sP和sNP大鼠之间，然后是P和NP大鼠之间的中间差异，而与HAD和LAD大鼠相比则存在较小差异。在所有偏好的品系中，P，HAD1和HAD2大鼠具有相似的行为特征，而AA和sP大鼠彼此之间和彼此之间存在很大差异。在所有酒精偏爱的品系中，没有一个单一的性状形成与高饮酒表型有关的共同“途径”。在不同的偏爱酒精的品系中发现的明显行为差异可能会模仿人类酒精亚型中观察到的异质性。

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