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首页> 外文期刊>Addiction biology >MR spectroscopy in opiate maintenance therapy: Association of glutamate with the number of previous withdrawals in the anterior cingulate cortex
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MR spectroscopy in opiate maintenance therapy: Association of glutamate with the number of previous withdrawals in the anterior cingulate cortex

机译：鸦片维持治疗中的MR光谱：谷氨酸与前扣带回皮层先前停药次数的关联

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Pre-clinical research indicates that opioids reduce extracellular glutamate in acute opioid treatment, whereas during withdrawal, glutamatergic neurotransmission is increased and withdrawal symptoms can be blocked by glutamate receptor antagonists. The glutamate hypothesis of addiction suggests that withdrawal-associated hyperglutamatergic states destabilize the glutamatergic system chronically and contribute to relapse. magnetic resonance spectroscopy at three tesla optimized for glutamate assessment (TE 80 ms) was performed in the anterior cingulate gyrus (ACC) and frontal white matter (fWM) of 17 opiate-dependent patients during opiate maintenance therapy and 20 healthy controls. Controlling for age and gray matter content, glutamate in the ACC was positively associated with the number of previous withdrawals. For glutamate + glutamine (Glx), a significant group-age interaction was found. Whereas Glx declines with age in healthy controls, Glx increases with age in opiate-dependent patients. The number of previous withdrawals did not correlate with age. In fWM spectra, increased Cho concentrations were observed in opiate-dependent patients. Both new findings, the positive correlation of glutamate and previous withdrawals and increasing Glx with age in contrast to an age-dependent Glx decrease in controls indicate a destabilization of the glutamate system in opiate-dependent patients and support the glutamate hypothesis of addiction. Increased Cho concentrations in fWM corroborate findings of WM abnormalities in opioid-dependent subjects.
机译：临床前研究表明，阿片类药物在急性阿片类药物治疗中可减少细胞外谷氨酸，而在戒断期间，谷氨酸能神经传递增加，且谷氨酸受体拮抗剂可阻断戒断症状。谷氨酸成瘾假说表明，与戒断相关的高谷氨酸能状态长期破坏谷氨酸能系统的稳定性，并有助于复发。在17例鸦片依赖性患者和鸦片维持治疗期间，在3个特斯拉针对谷氨酸评估（TE 80 ms）进行了优化的谷氨酸的磁共振波谱分析，测定了前扣带回（ACC）和额叶白质（fWM）。控制年龄和灰质含量，ACC中的谷氨酸与以前的戒断次数呈正相关。对于谷氨酸+谷氨酰胺（Glx），发现了显着的群体年龄相互作用。在健康对照组中，Glx随着年龄的增长而下降，而在鸦片依赖性患者中，Glx随着年龄的增长而增加。以前的退出次数与年龄无关。在fWM光谱中，在鸦片依赖性患者中观察到Cho浓度升高。两项新发现，谷氨酸和先前戒断的正相关性以及随着年龄增长的Glx与对照组中依赖年龄的Glx减少相反，都表明鸦片依赖性患者的谷氨酸系统不稳定，并支持了谷氨酸成瘾假说。 fWM中增加的Cho浓度证实了阿片类药物依赖性受试者WM异常的发现。

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