Revisiting metaplasticity: The roles of calcineurin and histone deacetylation in unlearning odor preference memory in rat pups

Sriya Bhattacharya; Bandhan Mukherjee; Jaqueline Blundell; Carolyn W. Harley; Qi Yuan

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Revisiting metaplasticity: The roles of calcineurin and histone deacetylation in unlearning odor preference memory in rat pups

机译：重新审视荟萃塑造性：钙调素和组蛋白脱乙酰化在大鼠幼仔中无学习气味偏好记忆中的作用

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Previous work has shown that 24?h duration odor preference learning, induced by one-trial training, generates a down-regulation of the GluN1 receptor in anterior piriform cortex at 3?h, and results in metaplastic unlearning if a second training trial is given at 3?h. The GluN1 receptor upregulates at 24?h so 24?h spaced training is highly effective in extending memory duration. The present study replicates the piriform cortex unlearning result in the olfactory bulb circuit and further studies the relationship between the initial training strength and its associated metaplastic effect. Intrabulbar infusions that block calcineurin or inhibit histone deacetylation normally produce extended days-long memory. If given during training, they are not associated with GluN1 downregulation at 3?h and do not recruit an unlearning process at that time. The two memory strengthening protocols do not appear to interact, but are also not synergistic. These outcomes argue that it is critical to understand the metaplastic effects of training in order to optimize training protocols in the service of either memory strengthening or of memory weakening.

机译：先前的工作表明，通过一次试验训练引起的24个？H持续时间偏好学习，在3〜H处产生前粒性皮质中的GLUN1受体的下调，并且如果给出第二次训练试验在3？h。 Glun1受体在24℃上调24℃，SO 24℃间隔训练在延长内存持续时间方面非常有效。本研究复制了液体灯泡电路中的圆形皮层未经阅读的结果，进一步研究了初始训练强度与其相关的沟槽效果之间的关系。阻断钙素或抑制组蛋白脱乙酰化通常产生延长的日期延长存储器。如果在培训期间给出，它们与3？H的GLUN1下调无关，那时不会招募一个无学习的过程。两个内存加强协议似乎没有互动，但也不是协同作用。这些结果争辩说，了解培训的沟通效果是至关重要的，以便优化在能够加强或记忆削弱的中记忆的服务中的培训方案。

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来源
《Neurobiology of learning and memory》 |2018年第2018期|共8页
作者
Sriya Bhattacharya; Bandhan Mukherjee; Jaqueline Blundell; Carolyn W. Harley; Qi Yuan;
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Psychology Department Faculty of Science Memorial University of Newfoundland;

Biomedical Sciences Faculty of Medicine Memorial University of Newfoundland;

Psychology Department Faculty of Science Memorial University of Newfoundland;

Psychology Department Faculty of Science Memorial University of Newfoundland;

Biomedical Sciences Faculty of Medicine Memorial University of Newfoundland;

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正文语种 eng
中图分类神经病学与精神病学;
关键词
Metaplasticity; NMDA receptor; GluN1; Calcineurin; Histone deacetylation; Odor preference learning;

机译：血管塑性;NMDA受体;GLUN1;钙调解素;组蛋白脱乙酰化;气味偏好学习;

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1. Revisiting metaplasticity: The roles of calcineurin and histone deacetylation in unlearning odor preference memory in rat pups [J] . Sriya Bhattacharya, Bandhan Mukherjee, Jaqueline Blundell, Neurobiology of learning and memory . 2018,第期

机译：重新审视荟萃塑造性：钙调素和组蛋白脱乙酰化在大鼠幼仔中无学习气味偏好记忆中的作用
2. Learning-Induced Metaplasticity? Associative Training for Early Odor Preference Learning Down-Regulates Synapse-Specific NMDA Receptors via mGluR and Calcineurin Activation [J] . Mukherjee Bandhan, Harley Carolyn W., Yuan Qi Cerebral cortex . 2017,第1期

机译：学习诱发的沟塑性？早期气味偏好的关联培训学习通过MGLUR和CAPLINEWORIN激活来降低突出调节突触特异性NMDA受体
3. Lateralized odor preference training in rat pups reveals an enhanced network response in anterior piriform cortex to olfactory input that parallels extended memory [J] . FontaineC.J., HarleyC.W., YuanQ. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2013,第38期

机译：在大鼠幼仔中进行侧向气味偏爱训练后，发现梨状前皮层对嗅觉输入的网络反应增强，与延长的记忆平行
4. Cardiac Cell Hypertrophy In Vitro Role of Calcineurin/NFAT as Ca~(2+)Signal Integrators [C] . MATILDE COLELLA, TULLIO POZZAN Larry Horti Fairberg Workshop on Control and Regulation of Transport Phenomena in Biological Systems with Special Emphasis on the Cardiac System . 2008

机译：Carchineurin / NFAT作为CA〜（2+）信号积分器的心脏细胞肥大
5. The role of diapause and host fruit odor preference in sympatric race formation of Rhagoletis pomonella. [D] . Dambroski, Hattie Rita. 2005

机译：滞育和寄主果实气味偏好在罗汉果小孢子虫同胞种族形成中的作用。
6. Histone deacetylase inhibition induces odor preference memory extension and maintains enhanced AMPA receptor expression in the rat pup model [O] . Sriya Bhattacharya, Bandhan Mukherjee, Jules J.E. Doré, 2017

机译：组蛋白脱乙酰基酶抑制诱导气味偏好记忆扩展并在大鼠幼仔模型中维持增强的AMPA受体表达
7. Unlearning: NMDA Receptor-Mediated Metaplasticity in the Anterior Piriform Cortex Following Early Odor Preference Training in Rats [O] . B. Mukherjee, G. L. Morrison, C. J. Fontaine, 2014

机译：无学习：NMDA受体介导的大鼠早期气味偏好训练后前痔疮的荟萃塑性

Revisiting metaplasticity: The roles of calcineurin and histone deacetylation in unlearning odor preference memory in rat pups

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