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首页> 外文期刊>Nutrition & Food Science >Effect of Ajuga iva on enzymes involved in the metabolism of cholesterol, in rat fed a cholesterol-enriched diet
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Effect of Ajuga iva on enzymes involved in the metabolism of cholesterol, in rat fed a cholesterol-enriched diet

机译：Ajuga IVA对参与胆固醇代谢的酶的影响，大鼠喂养胆固醇富含胆固醇的饮食

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Purpose - This study aims to investigate the effect of Ajuga iva (Ai) on enzymes involved in the metabolism of cholesterol, in rat fed a cholesterol-enriched diet.Design/methodology/approach - Male Wistar rats (n = 12), weighing 120 ± 5 g were fed on 1 per cent cholesterol-enriched diet [hypercholesterolemia (HQ] for 15 days (dl5). After this adaptation phase, HC rats (total cholesterol = 6.5 ± 0.6mmol/L) were divided into two groups fed the same diet and treated (Ai-Ш) or not with (HC) with Ai for dl5.Findings - At day 15, in Лг'-НС group compared to HC, serum triacylglycerol (TG) values were 1.4-fold lower (￡ = 0.002), whereas unesterified cholesterol (UC) contents were 1.8-fold higher (￡ = 0.0001). Serum phospholipids (PL) and cholesteryl esters (CE) contents and liver TG, UC, PL and CE values were not sensitive to Ai. TC/HDL-C and LDL-HDL1-C/HDL-C ratios were, respectively, 1.8- and 4-fold lower (￡ = 0.006 and p = 0.04). HDL2-C and HDL3-C amounts were enhanced by 40 and 74 per cent, respectively (p = 0.003 and p = 0.0001). HDL3-UC was 1.6-fold higher (￡ = 0.006); whereas PL contents were 1.4-fold lower ip= 0.003). HDL3-apo and HDL2-CE contents were similar between groups. A decreased of hydroxy-methyl-glutaryl-coenzyme A reductase and cholesterol 7a-hydroxylase activities (-44 and -25 per cent; p = 0.003 and p = 0.02, respectively) were noted. Lecithin: cholesterol acyltransferase activity was 1.5-fold higher (p = 0.001). Originality/value - In HC rat, Ai is able to induce hypotriglyceridemia. However, it turns out that Ai may reduce cardiovascular risk by decreasing the reports of atherogenicity and modifying the activities of enzymes involved in the cholesterol metabolism.
机译：目的 - 本研究旨在探讨Ajuga IVA（AI）对参与胆固醇代谢的酶的影响，在大鼠喂养胆固醇富含饮食的大鼠.Design/methodology/approch - 雄性Wistar大鼠（n = 12），称重120 ±5g富含1％的胆固醇富含饮食[高胆固醇血症（HQ] 15天（DL5）。在这种适应阶段之后，将HC大鼠（总胆固醇= 6.5±0.6mmol / L）分为喂养的两组与DL5.Findings的AI相同的饮食和治疗（AI-ш）与（HC） - 在第15天，与HC相比，在ЛГ'-НС组中，血清三酰基甘油（TG）值下降1.4倍（£= 0.002），而未经答题的胆固醇（UC）含量高出1.8倍（= 0.0001）。血清磷脂（PL）和胆汁甾醇酯（CE）含量和肝脏TG，UC，PL和CE值对AI不敏感。TC / HDL-C和LDL-HDL1-C / HDL-C比率分别为1.8-和4倍（= 0.006和P = 0.04）。HDL2-C和HDL3-C量增强40和74百分分别（p = 0.003和p = 0.0001）。 HDL3-UC更高1.6倍（= 0.006）;虽然Pl含量为1.4倍以下IP = 0.003）。 HDL3-APO和HDL2-CE内容在组之间相似。注意到羟基 - 甲基 - 戊脲 - 辅酶A还原酶和胆固醇7A-羟化酶活性（-44和-25％; P = 0.003和P = 0.02）。卵磷脂：胆固醇酰基转移酶活性为1.5倍（P = 0.001）。原创性/值 - 在HC大鼠中，AI能够诱导红甘油苷血症。然而，事实证明，AI可以通过减少动脉发生性的报告和改变胆固醇代谢的酶活性来降低心血管风险。

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