Rapid Analysis of C3 Epimers of 25-Hydroxyvitamin D in Serum by LC-MS/MS

Liang Shun-Hsin; Carroll Frances

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Rapid Analysis of C3 Epimers of 25-Hydroxyvitamin D in Serum by LC-MS/MS

机译：LC-MS / MS在血清中的25-羟基乙多蛋白D的C3差分析

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The C3 epimers of 25-hydroxyvitamin D have lower bioactivity than the primary metabolites and, unless they are chromatographically separated, can cause clinical vitamin D levels to be overestimated. Raptor FluoroPhenyl columns provide baseline resolution of all key compounds, and the method established here allows accurate quantification in a fast, 5-min analysis time (7-min total cycle time). This method is recommended for laboratories interested in reporting C3 epimer concentrations separately in order to obtain more accurate results for the clinical diagnosis of vitamin D status.

机译：25-羟基乙多素D的C3差异与初级代谢物具有较低的生物活性，除非它们是色谱分离的，否则会导致临床维生素D水平升高。雷达氟苯基柱提供所有关键化合物的基线分辨率，这里建立的方法在快速，5分钟的分析时间（7分钟总循环时间）中允许精确定量。建议该方法用于有兴趣分别报告C3基础浓度的实验室，以便获得更准确的维生素D状态临床诊断结果。

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《LC GC North America》 |2017年第suppla期|共3页
作者
Liang Shun-Hsin; Carroll Frances;
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Restek Corp Bellefonte PA 16823 USA;

Restek Corp Bellefonte PA 16823 USA;

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原文格式 PDF
正文语种 eng
中图分类分析化学;
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1. Rapid Analysis of C3 Epimers of 25-Hydroxyvitamin D in Serum by LC-MS/MS [J] . Liang Shun-Hsin, Carroll Frances LC GC North America . 2017,第Suppla期

机译：LC-MS / MS在血清中的25-羟基乙多蛋白D的C3差分析
2. High-throughput measurement of 25-hydroxyvitamin D by LC-MS/MS with separation of the C3-epimer interference for pediatric populations [J] . Yang Yifei, Rogers Katherine, Wardle Robert, Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2016,第Null期

机译：通过LC-MS / MS高通量测定25-羟基维生素D并分离C3表象素干扰儿科人群
3. High-throughput measurement of 25-hydroxyvitamin D by LC-MS/MS with separation of the C3-epimer interference for pediatric populations [J] . Yang Yifei, Rogers Katherine, Wardle Robert, Clinica chimica acta: International journal of clinical chemistry and applied molecular biology . 2016,第Null期

机译：LC-MS / MS的高通量测量25-羟基苯胺D，分离C3均匀干扰对儿科群体的干扰
4. Approaches in Method Development and Determination of Endogenous 25-Hydroxyvitamin D3 in Rat Serum by Electrospray LC-MS/MS [C] . Rong Yi, Hong Zhang, Gina de Boer, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：电气喷雾LC-MS / MS方法开发和测定大鼠血清内源25-羟基乙多素D3的方法
5. Optimization of gradient chromatofocusing for the protein separation and LC-MS/MS determination of NGP1-01 in mouse serum, brain, and retina. [D] . Jogiraju, Harini. 2013

机译：梯度色谱聚焦的优化，用于蛋白质分离和LC-MS / MS测定小鼠血清，脑和视网膜中的NGP1-01。
6. Misleading measures in Vitamin D analysis: A novel LC-MS/MS assay to account for epimers and isobars [O] . Iltaf Shah, Ricky James, James Barker, 2011

机译：维生素D分析中的误导性措施：解释差向异构体和等压线的新型LC-MS / MS分析
7. Simultaneous quantification of vitamin D₃, 25-hydroxyvitamin D-3 and 24,25-dihydroxyvitamin D₃ in human serum by LC-MS/MS [O] . Burild Anders, Frandsen Henrik Lauritz, Jakobsen Jette 2014

机译：通过LC-ms / ms同时定量测定人血清中维生素D _{3 ，25-hydroxyvitamin D-3和24,25-dihydroxyvitamin D ₃}
8. GC-MS LC-MS and LC-MS/MS of Soil Samples from a Former Mustard Storage Site for the Presence of Mustard Thiodiglycol and Related Compounds [R] . D'Agostino, P. A. , Hancock, J. R. , Chenier, C. L. 2004

机译：来自前芥子贮存场的土壤样品的GC-ms LC-ms和LC-ms / ms，用于存在芥子硫二甘醇和相关化合物

Rapid Analysis of C3 Epimers of 25-Hydroxyvitamin D in Serum by LC-MS/MS

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