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Functional measures, inflammatory markers and endothelin-1 as predictors of 360-day survival in centenarians

机译：功能性指标，炎症标记物和内皮素-1可预测百岁老人360天生存率

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Centenarians represent a rapidly growing population. To better characterize this specific age group, we have performed a cross-sectional study to observe associations between functional measures and a range of biochemical markers, including inflammatory markers and their significance as predictors of 360-day survival. Medical history and physical and functional assessment (Mini-Mental State Examination (MMSE), Katz Index (activities of daily living, ADL) and Barthel Index (Barthel Index) of Activities of Daily Living, and Lawton Instrumental Activities of Daily Living Scale (Lawton IADL)) were conducted on 86 101.9 +/- 1.2-year-old (mean +/- SD) subjects (70 women, 16 men). Blood tests were performed on 84 subjects of whom 43 also had extended biomarker assessment. As a reference group 30 51.8 +/- 5.0-year old healthy subjects (20 women, 10 men) were recruited. The centenarians received follow-up phone calls. Fifty-two centenarians (60 %) survived >= 360 days. Longer survival was associated with higher MMSE (hazard ratio, HR = 0.934, 95 % confidence interval (CI) 0.896-0.975, P = .002), ADL (HR = 0.840, 95 % CI 0.716-0.985, P = .032), Barthel Index (HR = 0.988, 95 % CI 0.977-0.999, P = .026), and albumin level (HR .926, 95 % CI 0.870-0.986, P .016) and with lower white blood cell (WBC) (HR = 1.161, 95 % CI 1.059-1.273, P = .001), Creactive protein (CRP) (HR = 1.032, 95 % CI 1.014-1.050, P < .001), IL-6 (HR = 1.182, 95 % CI 1.047-1.335, P = .007), and endothelin-1 (ET-1) level (HR = 3.711, 95 % CI 1.233-11.169, P = .020). Centenarians had higher 360-day survival probability with MMSE >= 13 (P < .001), ADL >= 1 (P < .001), Barthel Index >= 15 (P < .001), Lawton IADL >= 10 points (P = .009), WBC < 8.3 G/L (P = .039), CRP <10 mg/L (P < .001), IL-6 < 6 pg/mL (P .002), and ET-1 <1.1 pg/mL (P .007). Our results indicate that functional measures, inflammatory markers, and endothelin-1 are predictors of 360-day survival in centenarians.
机译：百岁老人代表着快速增长的人口。为了更好地表征这个特定年龄组，我们进行了一项横断面研究，以观察功能性措施与一系列生化标志物（包括炎症标志物）之间的关联以及它们作为360天生存预测因子的意义。病史和身体和功能评估（最低精神状态检查（MMSE），Katz指数（日常生活活动，ADL）和Barthel指数（Barthel指数）以及日常生活活动的劳顿工具活动量表（劳顿） IADL））在86个101.9 +/- 1.2岁（平均+/- SD）受试者（70名女性，16名男性）中进行。对84位受试者进行了血液检查，其中43位也进行了生物标志物评估。作为参考组，招募了30 51.8 +/- 5.0岁的健康受试者（20名女性，10名男性）。百岁老人接到了后续电话。 52位百岁老人（60％）存活> = 360天。更长的生存期与更高的MMSE（危险比，HR = 0.934，95％置信区间（CI）0.896-0.975，P = .002），ADL（HR = 0.840，95％CI 0.716-0.985，P = .032）有关，Barthel指数（HR = 0.988，95％CI 0.977-0.999，P = .026）和白蛋白水平（HR .926，95％CI 0.870-0.986，P .016）和白细胞较低（WBC）（ HR = 1.161，95％CI 1.059-1.273，P = .001），活性蛋白（CRP）（HR = 1.032，95％CI 1.014-1.050，P <.001），IL-6（HR = 1.182，95％ CI 1.047-1.335，P = .007）和内皮素1（ET-1）水平（HR = 3.711，95％CI 1.233-11.169，P = .020）。百岁老人在MMSE> = 13（P <.001），ADL> = 1（P <.001），Barthel Index> = 15（P <.001），Lawton IADL> = 10分时具有更高的360天生存率（ P = .009），WBC <8.3 G / L（P = .039），CRP <10 mg / L（P <.001），IL-6 <6 pg / mL（P .002）和ET-1 <1.1 pg / mL（P .007）。我们的结果表明，功能性指标，炎症标志物和内皮素-1是百岁老人360天生存的预测指标。

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