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Retinopathy in young retinoblastoma patients receiving a chemotherapy treatment: clinical trials and morphometric analysis

机译：患有化疗治疗的年轻视网膜母细胞瘤患者的视网膜病变：临床试验和形态学分析

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Background: This research is to evaluate patients with retinoblastoma, who receive chemotherapy, with enhanced depth imaging spectral-domain optical coherence tomography (EDI-OCT) to compare the signs of retinopathy. Materials and Methods: A prospective non-randomized trial included 125 eyes of 74 patients at the age of 24 +/- 1.6 months with retinoblastoma. All patients underwent an ophthalmoscopic examination and EDI-OCT before therapeutic treatment. The test group consisted of 55 patients, who underwent a course of chemotherapy. Patients were divided into two groups depending on the type of chemotherapy. Group #1 patients received six cycles of systemic intravenous chemotherapy treatment, ophthalmoscopic examination, and EDI-OCT occurred after third cycle and sixth cycle. Group #2 underwent three cycles of IVC chemotherapy treatment, and then local chemotherapy - three cycles of super-selective intra-arterial chemotherapy for exophytic retinoblastoma and 9 procedures of intravitreal (IVT) for endophytic retinoblastoma. Eyes in the control group were affected by eccentric neoplasms but macula and the optic nerve were not damaged. Results: After six cycles of IVC chemotherapy treatment, Group #1 history expanded with atrophy-induced peripapillary nerve fiber layer thinning (33.9%). At three cycle of super-selective intra-arterial chemotherapy, OCT imaging in Group #2 revealed more related symptoms like retinal vascular distention in peritumoral area. After systemic and intravitreal chemotherapy, macular puckers and small hyperreflective dotted foci in the inner retina were tracked. In Group #3 affected by peripheral tumors, the topographic anatomy of the macula was normal prior to therapy. Conclusion: Profound morphometric disturbances that come with combined chemotherapy call for a more careful treatment with methods selected in terms of OCT findings and specific chemotherapy contraindications.
机译：背景：本研究是评估接受化疗的视网膜母细胞瘤患者，增强深度成像光谱域光学相干断层扫描（EDI-OCT）以比较视网膜病变的迹象。材料和方法：预期的非随机试验包括125只眼睛，74名患者24岁+/- 1.6个月，视网膜母细胞瘤。所有患者在治疗治疗前都经历过眼科检查和EDI-OCT。测试组由55名患者组成，患者接受了化疗疗程。根据化疗的类型，患者分为两组。组＃1患者接受了六个全身静脉化疗化疗治疗，眼科检查和EDI-OCT发生在第三周期和第六周期后。组＃2进行了三个循环的IVC化疗治疗，然后是局部化疗 - 三个循环的超选择性内动脉化疗，用于异常视网膜母细胞瘤和9个内核视网膜母细胞瘤的玻璃体内（IVT）程序。对照组的眼睛受到偏心瘤的影响，但黄斑和视神经没有损坏。结果：经过六个循环的IVC化疗治疗后，组＃1历史扩增萎缩诱导的跨越神经纤维层稀释（33.9％）。在三个循环的超选择性动脉内化疗，第2组中的OCT成像显示出更多相关的症状，如Peritumoral区域的视网膜血管间隙。经过全身和玻璃体内化疗后，跟踪内视网膜中的黄斑褶皱和小过粗焦点。在受外周期肿瘤影响的第3组中，治疗前的蛋黄酱的地形解剖学是正常的。结论：组合化疗呼吁的深刻形态紊乱，用八八型调查结果和特定化疗禁忌症选择的方法更加仔细处理。

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