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首页> 外文期刊>Prevention science: the official journal of the Society for Prevention Research >Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation
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Prevention of Early Substance Use Mediates, and Variation at SLC6A4 Moderates, SAAF Intervention Effects on OXTR Methylation

机译：预防早期物质使用介质，以及SLC6A4调节的变化，SAAF干预对OXTR甲基化的影响

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Abstract The Strong African American Family (SAAF) program has been shown to have a variety of short and long-term benefits for participating youth and families. However, biological mechanisms potentially influencing long-term effects on resilience in young adulthood have not been examined. In the current investigation, we examine the effects of SAAF on methylation of the OXTR gene in young adulthood, focusing on a regulatory region previously identified to be both responsive to stress and implicated in resilience. Using the subsample of participants from the original study for whom methylation data was available ( N = 388), we replicated the previously reported G 鼸 effect on prevention of early substance use and then examined whether there would also be a moderated effect on OXTR methylation in early adulthood, with s allele carriers, but not LL participants, showing a significant indirect effect of SAAF on OXTR methylation. Results suggest that for susceptible youth (i.e., s allele carriers), preventive intervention may get under the skin, in a manner potentially beneficial for long-term outcomes. Implications for examination of OXTR methylation in future prevention research are discussed.
机译：摘要展示了强大的非洲裔美国家庭（SAF）计划为参与的青年和家庭提供了各种短期和长期福利。然而，尚未检查潜在地影响年轻成年期恢复性的长期影响的生物机制。在目前的研究中，我们研究SAAF对Oxtr基因甲基化对年轻成年的影响，重点是先前识别的调节区域响应于应力并涉及弹性。使用与参与者的子样本从甲基化数据可用的原始研究中（n = 388），我们将先前报道的g≠对预防早期物质使用的影响进行了复制，然后检查是否还有对oxtr甲基化的调节效果成年早期，具有S等位基因载体，但不是LL参与者，显示出SAAF对OXTR甲基化的显着间接影响。结果表明，对于易感青年（即，S等位基因载体），预防性干预可能会在皮肤下，以可能有利于长期成果。讨论了对未来预防研究中oxtr甲基化检查的影响。

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