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A case of lupus vasculopathy presenting favorable renal outcome

机译：狼疮血管病的案例呈现有利的肾果糖

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Noninflammatory necrotizing vasculopathy, also referred to as lupus vasculopathy, is not infrequently observed in the pathology of lupus nephritis. It affects vessels causing them to become severely narrowed and occluded by a mechanism involving immune complexes. We experienced a 51-year-old woman with lupus nephritis class IV + V, which was accompanied by lupus vasculopathy. Renal biopsy and light microscopy showed eosinophilic hyaline-like material in the afferent and/or efferent arterioles, which narrowed the lumen, and which were positive for IgG by immunofluorescent analysis. Electron microscopy indicated that amorphous material and endothelial detachment occluded the arterioles. These findings were consistent with those of lupus vasculopathy. We treated the patient with steroids and cyclophosphamide. By the day of discharge, her levels of creatinine and proteinuria had undergone partial remission. Although lupus vasculopathy was implied as a lesion with unfavorable renal prognosis, some recent reports suggest its true renal prognosis is not unfavorable necessarily. Nevertheless, lupus vasculopathy is an important finding in diagnosis in contradiction to other vascular legions in systemic lupus erythematosus. In addition, a standard therapy has also not been established. Therefore, it is important to accumulate cases of lupus vasculopathy to determine its prognosis and develop standard treatments.
机译：在狼疮性肾炎的病理学中，非炎症坏死血管病变，也被称为狼疮血管病变。它会影响导致它们被涉及免疫复合物的机制严重变窄和封闭的容器。我们经历了一个51岁的女性，狼疮肾炎级+ v，伴随着狼疮血管病变。肾活检和光学显微镜显示出传入和/或兴奋剂中的嗜酸性透明样材料，其缩小了腔，并通过免疫荧光分析为IgG为阳性。电子显微镜表明无定形材料和内皮脱离堵塞了动脉瘤。这些发现与狼疮血管病变一致。我们用类固醇和环磷酰胺对待患者。在排放日，她的肌酐和蛋白尿的水平经历了部分缓解。虽然狼疮血管病患者被暗示为具有不利肾预后的病变，但最近的一些报告表明其真正的肾预言必然是不利的。然而，狼疮血管病是矛盾的重要发现，矛盾的其他血管动物在全身性狼疮红斑狼疮中。此外，也没有建立标准治疗。因此，重要的是积累狼疮血管病变，以确定其预后和制定标准治疗。

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