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首页> 外文期刊>Prostaglandins and Other Lipid Mediators >Postpartum levels of 8-iso-prostaglandin F-2 alpha in plasma and milk phospholipid fractions as biomarker of oxidative stress in first-lactating dairy cows
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Postpartum levels of 8-iso-prostaglandin F-2 alpha in plasma and milk phospholipid fractions as biomarker of oxidative stress in first-lactating dairy cows

机译：在血浆和乳磷脂中的8-Iso-Fragglandin F-2α的产后水平作为第一乳汁奶牛中氧化应激的生物标志物

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F-2-isoprostanes such as 8-iso-prostaglandin F2 alpha (8-ISO-PGF(2 alpha)) are formed by free radical-catalyzed mechanisms from membrane phospholipids and from low density lipoproteins through peroxidation of arachidonic acid. Esterified 8-iso-PGF(2 alpha) is cleaved by phospholipases, circulates in blood and is excreted as putatively harmful oxidatively modified lipid via the kidney into urine. In this study we demonstrate that 8-iso-PGF(2 alpha) concentrations in plasma samples from heifers are higher (p < 0.005) compared to those from first-lactating dairy cows at 71 days postpartum. Furthermore, plasma 8-iso-PGF(2 alpha) concentrations vary with ovarian activity and differ in response to luteolytic initiation as well as activation of the hypothalamic pituitary gonadal axis between heifers and first-lactating cows. Sustainable concentrations of 8-iso-PGF(2 alpha) (50-150 pg/ml) are detectable in the phospholipid fraction of milk, suggesting milk as an additional excretion route for 8-isoprostanes. Plasma levels largely paralleled levels in milk (p < 0.001). Plasma phospholipid 8-iso-PGF2a concentrations in cyclic cows decreased (p < 0.05) from day 38 to day 71 postpartum, whereas milk phospholipid 8-iso-PGF(2 alpha) rather increased (p < 0.05). Cyclic cows tend to have higher 8-isoprostane levels compared to acyclic animals. In contrast to lipohydroperoxides, concentration of 8-iso-PGF(2 alpha) were not correlated with milk yield (p > 0.05). Our data indicate 8-iso-PGF(2 alpha) may be a novel biomarker of oxidative stress in dairy cow, which is detectable in blood as well as in milk. (C) 2014 Elsevier Inc. All rights reserved.
机译：F-2 - 异丙烷如8-异丙锭F2α（8-ISO-PGF（2α）由来自膜磷脂的自由基催化机制和低密度脂蛋白通过过氧化氧化酸的机理形成。磷酸酶酯化的8-ISO-PGF（2α）被磷酸酶切割，血液中循环，并通过肾脏将氧化改性脂质作为尿液排出。在该研究中，我们证明，与第71天产后的第一乳酸奶牛相比，来自小母牛的血浆样品中的8-ISO-PGF（2α）浓度更高（P <0.005）。此外，等离子体8-ISO-PGF（2α）浓度随卵巢活性而变化，并且响应于琵盐引发以及丘脑垂直性腺轴的激活，并且在海外母牛和第一哺乳期奶牛之间的激活。可持续浓度为8-ISO-PGF（2α）（50-150pg / ml）可检测在牛奶的磷脂级分中，表明牛奶作为8-茴香烷的额外排泄途径。血浆水平在牛奶中大部分平行水平（P <0.001）。循环奶牛中的血浆磷脂8-ISO-PGF2A浓度从第38天至第71天的第38天降低（P <0.05），而乳磷脂8-ISO-PGF（2α）相当增加（P <0.05）。与无循环动物相比，循环奶牛往往具有更高的8-异前烷水平。与脂氢过氧化物相比，8-ISO-PGF（2α）的浓度与牛奶产率不相关（P> 0.05）。我们的数据表明了8-ISO-PGF（2α）可以是奶牛中氧化胁迫的新型生物标志物，可在血液以及牛奶中检测到。 （c）2014年elsevier Inc.保留所有权利。

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