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The Effect of Psychosocial Factors on Success Rates of Hepatitis C Treatment

机译：心理社会因素对丙型肝炎治疗成功率的影响

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Objective Our study was to determine which psychosocial factors interfere with patients reaching sustained virologic response (SVR), a marker for hepatitis C virus eradication. Methods A retrospective chart review was performed between January 6, 2015 and February 24, 2016. The primary outcome was to assess which social and psychological factors may interfere with patients reaching SVR. SVR was defined as having an undetectable viral load 12 weeks after the completion of the treatment regimen. Bivariate analysis was followed by a multivariate logistic regression analysis to determine significant factors for SVR. Depression and generalized anxiety disorder were included. Results A total of 204 patients completed treatment within the designated time frame and were included in the final analysis. Social or home support was associated with SVR (odds ratio = 7.0, p = 0.02). Cocaine use was also a significant factor predicting SVR. Historical cocaine use compared with active cocaine use during treatment was associated with an odds ratio of SVR of 39.3 ( p = 0.04). Interestingly, historical cocaine use vs no history of cocaine use did not influence SVR. No history of depression or generalized anxiety disorder was associated with a higher rate of SVR (odds ratio = 10.4, p = 0.05). No depression/generalized anxiety disorder compared with untreated depression/generalized anxiety disorder was associated with a 13.1 times greater rate of SVR ( p = 0.04). Conclusion It is important to recognize and address psychosocial factors related to mental illness and active cocaine addictions before hepatitis C virus treatment. Furthermore, patients without home or social support are at greater risk for failing treatment, thus strategies to provide support during treatment are necessary.
机译：目的我们的研究是确定哪些心理社会因素干扰患者达到持续的病毒性反应（SVR），丙型肝炎病毒的标志物。方法回顾性图表审查是在2016年1月6日和2016年2月24日之间进行的。主要结果是评估哪些社会和心理因素可能会干扰达到SVR的患者。在治疗方案完成后12周定义SVR被定义为具有不可检测的病毒载荷。双变量分析随后是多变量逻辑回归分析，以确定SVR的重要因素。包括抑郁和广泛性焦虑症。结果共有204名患者在指定时间范围内完成治疗，并包含在最终分析中。社交或家庭支持与SVR相关联（差价率= 7.0，P = 0.02）。可卡因使用也是预测SVR的重要因素。与活性可卡因相比使用的历史可卡因使用与39.3的SVR的比率比有关（P = 0.04）。有趣的是，历史可卡因使用VS没有可卡因的历史不影响SVR。没有抑郁症或广义焦虑症的历史与较高的SVR速率相关（差距= 10.4，P = 0.05）。与未经治疗的抑郁症/广义焦虑症相比，没有抑郁症/广义焦虑症与SVR率较高的13.1倍（P = 0.04）相关。结论重要的是要识别和解决与丙型肝炎病毒治疗前的精神疾病和活性可卡因成瘾有关的心理社会因素。此外，没有家庭或社会支持的患者对失败治疗的风险更大，因此需要在治疗过程中提供支持的策略。

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