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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Effectiveness of Albendazole for Hookworm Varies Widely by Community and Correlates with Nutritional Factors: A Cross-Sectional Study of School-Age Children in Ghana
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Effectiveness of Albendazole for Hookworm Varies Widely by Community and Correlates with Nutritional Factors: A Cross-Sectional Study of School-Age Children in Ghana

机译：群体的阿美唑的有效性被社区广泛变化，与营养因素相关：加纳学龄儿童的横断面研究

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Mass drug administration (MDA) targeting school-age children is recommended by the World Health Organization for the global control of soil-transmitted helminth (STH) infections. Although considered safe and cost-effective to deliver, benzimidazole anthelminthics are variably effective against the three most common STHs, and widespread use has raised concern about the potential for emerging resistance. To identify factors mediating response to albendazole, we conducted a cross-sectional study of hookworm infection in the Kintampo North Municipality of Ghana in 2011. Among 140 school-age children residing in five contiguous communities, the hookworm prevalence was 59% (82/140). The overall cure rate following administration of single-dose albendazole (400 mg) was 35% (27/76), with a community-wide fecal egg reduction rate (ERR) of 61% (95% confidence interval: 51.8-71.1). Significant disparities were observed in albendazole effectiveness by community, with a cure rate as low as 0% (N = 24) in Jato Akuraa and ERRs ranging from 53% to 95% across the five study sites. Individual host factors associated with response to deworming treatment included time since last meal, pretreatment blood hemoglobin level, and mid-upper arm circumference. These data demonstrate significant community-level variation in the effectiveness of albendazole, even among populations living in close proximity. Identification of host factors that influence response to albendazole, most notably the timing of drug administration and nutritional factors, creates an opportunity to enhance the effectiveness of deworming through targeted interventions. These findings also demonstrate the importance of measuring anthelminthic response as part of the monitoring and evaluation of community-based deworming programs.
机译：世界卫生组织建议靶向学龄儿童的大规模药物管理局（MDA）全球卫生组织对土壤传播的蠕虫（STH）感染的全局控制。虽然被认为是安全且具有成本效益的递送，但苯并咪唑anthelminthics对三种最常见的STH有变异有效，并且广泛使用已经提出了对新兴抗性的可能性的担忧。为了鉴定向阿星唑的反应中调解反应的因素，我们在2011年在加纳克林纳北市钩虫感染进行了横断面研究。140名居住在五个连续社区中的140名学龄儿童中，捕获捕获量为59％（82/140 ）。施用单剂量阿比萨唑（400mg）后的整体治愈率为35％（27/76），群体宽的粪便蛋减少率（ERR）为61％（95％置信区间：51.8-71.1）。在群落中，在群组中，在群组中的含量效果中观察到显着的差异，在Jato Akuraa的治愈率低至0％（n = 24），并且在五个研究网站上的53％至95％的错误。与对驱虫治疗的反应相关的个体宿主因子包括自上一顿饭，预处理血液血红蛋白水平和中上臂周长的时间。这些数据表明，即使在生活在近距离的人口中，也表现出苯唑的有效性的变化。鉴定影响对阿星唑的反应的宿主因子，最特别是药物管理和营养因素的时间，创造了通过有针对性干预来提高驱虫的有效性的机会。这些调查结果还证明了作为对基于社区的驱逐计划的监测和评估的一部分来测量Anthelminthic反应的重要性。

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