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首页> 外文期刊>The anatomical record: advances in integrative anatomy and evolutionary biology >Myricetin Inhibits Breast Tumor Growth and Angiogenesis by Regulating VEGF/VEGFR2 and p38MAPK Signaling Pathways
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Myricetin Inhibits Breast Tumor Growth and Angiogenesis by Regulating VEGF/VEGFR2 and p38MAPK Signaling Pathways

机译：Myricetin通过调节VEGF / VEGFR2和P38MAPK信号通路来抑制乳腺肿瘤生长和血管生成

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ABSTRACT Tumor angiogenesis is an important cause of tumor growth and metastasis. Myricetin is a flavonoid component used in traditional Chinese medicine that has been demonstrated to have anticancer activity. However, to the best of our knowledge, the effect of myricetin on tumor angiogenesis remains unknown. The present study reports the identification of myricetin as a potential chemopreventive agent by reason of its inhibition of tumor angiogenesis and demonstrates the anticancer effects of myricetin in vivo . Cell Counting Kit‐8 assays revealed that myricetin inhibits the proliferation of tumor cells but not that of human umbilical vein endothelial cells (HUVECs), and a transwell assay demonstrated that myricetin could inhibit the migration of HUVECs. A rat aortic ring assay revealed that myricetin could also affect the development of microvessels and the formation of vascular networks. Further, an ELISA showed that myricetin reduced the levels of vascular endothelial growth factor (VEGF) in vivo and in vitro . Western blot analysis indicated that myricetin could downregulate VEGFR2 and p38MAPK. Therefore, myricetin could significantly inhibit tumor angiogenesis and has potential as a chemopreventive agent because of its inhibition to angiogenesis. Anat Rec, 302:2186–2192, 2019. ? 2019 American Association for Anatomy
机译：摘要肿瘤血管生成是肿瘤生长和转移的重要原因。 Myricetin是一种用于中药中的一种类黄酮组分，已被证明具有抗癌活动。然而，据我们所知，Myricetin对肿瘤血管生成的影响仍然未知。本研究通过抑制肿瘤血管生成的原因，报告了鉴定Myricetin作为潜在的化学预防剂，并证明了Myricetin在体内的抗癌作用。细胞计数试剂盒-8测定显示，Myricetin抑制肿瘤细胞的增殖，而不是人脐静脉内皮细胞（HUVEC），并且Transwell测定表明Myricetin可以抑制Huvecs的迁移。大鼠主动脉环测定显示，Myricetin也可能影响微血管的发育和血管网络的形成。此外，ELISA表明，Myricetin将血管内皮生长因子（VEGF）的水平降低于体内和体外。 Western印迹分析表明Myricetin可以下调VEGFR2和P38MAPK。因此，Myricetin可以显着抑制肿瘤血管生成，并且由于其对血管生成的抑制而具有化学预防剂。 ANAT REC，302：2186-2192,2019。？ 2019年美国解剖学协会

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