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首页> 外文期刊>The International journal of clinical and experimental hypnosis >HYPNOTIZABILITY-RELATED FAAH C385A POLYMORPHISM: POSSIBLE ENDOCANNABINOID CONTRIBUTION TO SUGGESTION-INDUCED ANALGESIA
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HYPNOTIZABILITY-RELATED FAAH C385A POLYMORPHISM: POSSIBLE ENDOCANNABINOID CONTRIBUTION TO SUGGESTION-INDUCED ANALGESIA

机译：催眠化相关的FAAH C385A多态性：可能对建议诱导的镇痛的促进贡献

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摘要

Fatty acid amide hydrolase (FAAH) degrades the endogenous endocannabinoid (eCB) anandamide and might be involved in the response to suggestions of analgesia in subjects with high hypnotizability scores (highs). Since the A allele of the FAAH C385A polymorphism (rs324420) is associated with lower FAAH activity, it was studied in 21 highs, 66 low hypnotizable individuals (lows), and 172 individuals not selected for hypnotizability (controls) representing the general population. No significant difference was observed among groups, but the A allele frequency showed a significant trend to increase from lows to controls and from controls to highs. Since eCB small differences can be amplified by eCB interactions with other neurotransmitters, a contribution of the FAAH polymorphism to the highs' analgesia should not be excluded.
机译：脂肪酸酰胺水解酶（FAAH）降解了内源性内甲醛（ECB）Anandamide，并且可以参与对具有高催眠增分（高级）的受试者镇痛建议的反应。 由于FAAH C385A多态性（RS324420）的等位基因与较低的FAAH活动相关，因此研究了21位高，66个低催眠的个体（低点），172名未选择代表一般人群的催眠增压（控制）。 在群体中没有观察到显着差异，但等位基因频率显示出从低谷增加和从控制到高度的重大趋势。 由于欧洲央行与其他神经递质的欧洲央行相互作用可以扩增ECB小差异，因此不应排除FAAH多态性对高级镇痛的贡献。

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