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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Antimicrobial and antibiofilm activities of ursolic acid against carbapenem-resistant Klebsiella pneumoniae
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Antimicrobial and antibiofilm activities of ursolic acid against carbapenem-resistant Klebsiella pneumoniae

机译：熊糖酸的抗菌和抗菌和抗菌性抗性Klebsiella肺炎肺炎

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摘要

Previous studies demonstrated that ursolic acid (UA) present in apple pomace displays antimicrobial activity against some microorganisms, but the underlying mechanisms associated with this activity remain unexplored. Furthermore, there are no reports on the effect of UA on carbapenem-resistant Klebsiella pneumoniae (CRKP). This study examined the antimicrobial activity and mode of action of UA against CRKP was examined. Minimum inhibitory concentration (MIC) of UA against CRKP was determined by the agar dilution method. Variations in the intracellular pH (pHin), ATP concentration, and cell membrane potential were measured to assess the influence of UA on the cell membrane. Our results show that UA was effective against CRKP at an MIC of 0.8 mg ml(-1). UA disrupted the cell membrane integrity of CRKP, exhibited strong inhibitory effects against biofilm formation and biofilm-related gene expression, and inactivated CRKP cells encased in biofilms. Thus, UA shows promise for use in combination with other antibiotics to treat multidrug resistant K. pneumoniae infections.
机译：以前的研究表明，苹果渣中存在的熊酸（UA）对某些微生物显示抗菌活性，但与此活动相关的潜在机制仍未探索。此外，没有关于UA对耐鲤鱼抗性肺炎肺炎（CRKP）的影响的报道。该研究检测了抗微生物活性和UA对CRKP的作用方式。通过琼脂稀释方法测定UA对CRKP的最小抑制浓度（MIC）。测量细胞内pH（phin），ATP浓度和细胞膜电位的变化以评估UA对细胞膜的影响。我们的结果表明，UA在0.8mg mL（-1）的MIC上对CRKP有效。 UA破坏了CRKP的细胞膜完整性，表现出对生物膜形成和生物膜相关基因表达的强烈抑制作用，并且在生物膜中包裹的灭活CRKP细胞。因此，UA显示了与其他抗生素组合使用以治疗多药抗性K.肺炎的感染。

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    Qian Weidong; Wang Wenjing; Zhang Jianing; Wang Ting; Liu Miao; Yang Min; Sun Zhaohuan; Li Xiang; Li Yongdong;

  • 作者单位

    Shaanxi Univ Sci &

    Technol Food Sci &

    Bioengn Sch Xian 710021 Peoples R China;

    Shaanxi Univ Sci &

    Technol Food Sci &

    Bioengn Sch Xian 710021 Peoples R China;

    Shaanxi Univ Sci &

    Technol Food Sci &

    Bioengn Sch Xian 710021 Peoples R China;

    Shaanxi Univ Sci &

    Technol Food Sci &

    Bioengn Sch Xian 710021 Peoples R China;

    Shaanxi Univ Sci &

    Technol Food Sci &

    Bioengn Sch Xian 710021 Peoples R China;

    Shaanxi Univ Sci &

    Technol Food Sci &

    Bioengn Sch Xian 710021 Peoples R China;

    Shaanxi Univ Sci &

    Technol Food Sci &

    Bioengn Sch Xian 710021 Peoples R China;

    Shaanxi Univ Sci &

    Technol Food Sci &

    Bioengn Sch Xian 710021 Peoples R China;

    Ningbo Municipal Ctr Dis Control &

    Prevent Ningbo 315010 Peoples R China;

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  • 正文语种 eng
  • 中图分类 药学;
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