Engineering nucleoside antibiotics toward the development of novel antimicrobial agents

Niu Guoqing; Li Zhilei; Huang Pengju; Tan Huarong

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Engineering nucleoside antibiotics toward the development of novel antimicrobial agents

机译：工程核苷抗生素朝着新型抗微生物剂的发展

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Antimicrobial resistance is a major threat for public health worldwide. Novel antimicrobial drugs are urgently needed to combat the growing prevalence of antimicrobial resistance. Nucleoside antibiotics represent a unique class of microbial natural products with distinctive structural features and diverse biological activities. We herein summarize recent findings on the biosynthesis of representative nucleoside antibiotics, and highlight recent advances in the discovery and rational generation of nucleoside antibiotics for the development of novel antimicrobial agents.

机译：抗微生物抗性是全球公共卫生的主要威胁。迫切需要新的抗微生物药物来对抗抗微生物抗性的普遍性。核苷抗生素代表着一种独特的微生物天然产物，具有独特的结构特征和不同的生物活性。我们在此总结了最近关于代表性核苷抗生素的生物合成的发现，并突出了核苷抗生素的发现和理性产生的最新进展，用于开发新的抗微生物剂。

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《The Journal of Antibiotics: An International Journal》 |2019年第12期|共7页
作者
Niu Guoqing; Li Zhilei; Huang Pengju; Tan Huarong;
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作者单位

Southwest Univ Biotechnol Res Ctr Chongqing 400715 Peoples R China;

Southwest Univ Biotechnol Res Ctr Chongqing 400715 Peoples R China;

Southwest Univ Biotechnol Res Ctr Chongqing 400715 Peoples R China;

Chinese Acad Sci Inst Microbiol State Key Lab Microbial Resources Beijing 100101 Peoples R China;

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正文语种 eng
中图分类药学;
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1. Engineering nucleoside antibiotics toward the development of novel antimicrobial agents [J] . Niu Guoqing, Li Zhilei, Huang Pengju, The Journal of Antibiotics: An International Journal . 2019,第12期

机译：工程核苷抗生素朝着新型抗微生物剂的发展
2. Recent Advances in the Development of Macrolide Antibiotics as Antimicrobial Agents [J] . Qin Yinhui, Ma Shutao Mini reviews in medicinal chemistry . 2020,第7期

机译：大环内德抗生素发展作为抗微生物剂的最新进展
3. Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance. [J] . Cassell GH, Mekalanos J JAMA: the Journal of the American Medical Association . 2001,第5期

机译：在新的和重新出现的传染病和增加的抗生素耐药性时代，抗菌剂的发展。
4. Essential Oil from Zantoxyllum tingoassuiba Loaded into Multilamellar Liposomes Useful as Antibiotic and Antimicrobial Agent [C] . E.C.M. Cabral-Albuquerque, S.V.A. Howlenweger, C.B. Dettoni, Controlled Release Society Annual Meeting and Exposition . 2007

机译：从花椒中提取的香精油装入多层脂质体中，可用作抗菌剂和抗菌剂
5. Development of efficient production platform of novel antimicrobial agents by malonyl-CoA overproduction and studying the antimicrobial efficacy. [D] . Shah, Karan Prakash. 2010

机译：通过丙二酰辅酶A的过量生产开发新型抗菌剂高效生产平台，并研究其抗菌功效。
6. Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents [O] . Daniel Wiegmann, Stefan Koppermann, Marius Wirth, 2016

机译：Muraymycin核苷肽抗生素：尿苷衍生的天然产物作为开发新型抗菌剂的先导结构
7. Muraymycin nucleoside-peptide antibiotics: uridine-derived natural products as lead structures for the development of novel antibacterial agents [O] . Daniel Wiegmann, Stefan Koppermann, Marius Wirth, 2016

机译：muraymycin核苷 - 肽抗生素：尿苷衍生的天然产物作为开发新型抗菌剂的先导结构

Engineering nucleoside antibiotics toward the development of novel antimicrobial agents

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