A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity.

Murakami R; Fujita Y; Kizuka M; Kagawa T; Muramatsu Y; Miyakoshi S; Takatsu T; Inukai M

首页> 外文期刊>The Journal of Antibiotics: An International Journal >A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity.

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A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity.

机译：A-94964，由Streptomyces SP产生的细菌易用酶I的新型抑制剂。 SANK 60404. I.分类，分离和生物活性。

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Bacterial phospho-N-acetylmuramyl-pentapeptide translocase (translocase I: EC 2.7.8.13) is a key enzyme in peptidoglycan biosynthesis, and a known target of antibiotics. Here we report a novel nucleoside inhibitor against translocase I, A-94964, isolated from the culture broth of the strain Streptomyces sp. SANK 60404. A-94964 inhibited bacterial translocase I with IC50 value of 1.1 microg/ml, and showed antimicrobial activities against Staphylococcus aureus and Enterococcus faecalis with MIC of 100 and 50 microg/ml, respectively. A-94964 did not show cytotoxicity against mammalian cell lines.

机译：细菌磷酸 - N-乙酰杂糠 - 戊肽叔肽（译式酶I：EC 2.7.8.13）是肽聚糖生物合成的关键酶，以及已知的抗生素靶标。在这里，我们报告了一种针对转译酶I，A-94964的新型核苷抑制剂，从菌株SpOrtomyces Sp的培养液中分离。 SANK 60404.A-94964抑制了用IC50值为1.1 microg / mL的细菌型转运酶I，并分别显示出与100和50微孔/ m的麦克风的葡萄球菌和肠球菌的抗微生物活性。 A-94964未显示对哺乳动物细胞系的细胞毒性。

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《The Journal of Antibiotics: An International Journal》 |2008年第9期|共8页
作者
Murakami R; Fujita Y; Kizuka M; Kagawa T; Muramatsu Y; Miyakoshi S; Takatsu T; Inukai M;
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Exploratory Research Laboratories II Daiichi-Sankyo Co. Ltd. 1-16-13 Kitakasai Edogawa-ku;

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正文语种 eng
中图分类药学;
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1. A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity. [J] . Murakami R, Fujita Y, Kizuka M, The Journal of Antibiotics: An International Journal . 2008,第9期

机译：A-94964，一种由Streptomyces sp。生产的新型细菌转座酶I抑制剂。 SANK60404。I.分类学，隔离和生物活性。
2. A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity. [J] . Murakami R, Fujita Y, Kizuka M, The Journal of Antibiotics: An International Journal . 2008,第9期

机译：A-94964，由Streptomyces SP产生的细菌易用酶I的新型抑制剂。 SANK 60404. I.分类，分离和生物活性。
3. A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity. [J] . Murakami R, Fujita Y, Kizuka M, The Journal of Antibiotics: An International Journal . 2008,第9期

机译：A-94964，由Streptomyces SP产生的细菌易用酶I的新型抑制剂。 SANK 60404. I.分类，分离和生物活性。
4. Isolation and characterization of marine sponge–associated Streptomyces sp. NMF6 strain producing secondary metabolite(s) possessing antimicrobial antioxidant anticancer and antiviral activities [O] . Nayer Mohamed Fahmy, Asmaa Mohamed Abdel-Tawab 2021

机译：海绵伴相关链霉菌SP的分离与表征。产生具有抗菌抗氧化剂抗癌和抗病毒活性的次级代谢物的NMF6菌株
5. A-94964, a Novel Inhibitor of Bacterial Translocase I, Produced by Streptomyces sp. SANK 60404 [O] . Ryo Murakami, Yoko Fujita, Masaaki Kizuka, 2008

机译：A-94964，一种新型细菌型千磷酶I抑制剂，由Streptomyces Sp产生。沉没60404.

A-94964, a novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. I. Taxonomy, isolation and biological activity.

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