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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >CD4:8 Ratio Above 5 Is Associated With All-Cause Mortality in CMV-Seronegative Very Old Women: Results From the BELFRAIL Study
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CD4:8 Ratio Above 5 Is Associated With All-Cause Mortality in CMV-Seronegative Very Old Women: Results From the BELFRAIL Study

机译：CD4：8比率5与CMV-SERONEGATIVE非常老年女性的全导致死亡率相关：来自BelfRAIL研究的结果

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摘要

The occurrence and general applicability of the CD4:8 ratio as a surrogate predictor of mortality among the oldest old have only been tested in a few longitudinal studies. Here, the predictive value of CD4:8 ratio for mortality with respect to the role of cytomegalovirus (CMV) infection was investigated. Using polychromatic flow cytometry, the CD4:8 ratio and T-cell subsets of 235 individuals aged 81.5 years or older were analyzed, and mortality data were collected after a mean period of 3.3 years. The hazard for all-cause mortality adjusted for age, comorbidity, and CMV serostatus increased 1.53-fold (95% CI:0.94-2.51) with every increment in the CD4:8 ratio from R < 1, to 1 < R < 5 and R > 5 among women. A negative hazard ratio of 0.50 for CMV seropositivity in women indicated an apparently protective effect of this virus. In men, no associations with survival were observed. No mediation effect could be found for the CD4:8 ratio with respect to the relationship between CMV serostatus and mortality. Very elderly CMV-negative women with a R > 5 experienced the highest mortality rates, independent of age and comorbidity. The associations of CMV serostatus and CD4:8 ratio with mortality seem to reflect distinct pathways mediating life span in very old humans.
机译：CD4：8比例作为替代老年人死亡率的替代预测因子的发生和一般适用性仅在少数纵向研究中进行了测试。在此，研究了CD4：8对尖端胞嘧啶（CMV）感染的作用的死亡率的预测值。分析了多色流式细胞术，分析了81.5岁或以上的235岁或以上的235岁的CD4：8比和T细胞亚群，平均3.3岁后收集死亡数据。调整AGE，合并症和CMV Serostatus调整的全因死亡率的危害增加了1.53倍（95％CI：0.94-2.51），每次增加到R <1，1 妇女中5个。女性中CMV血清阳性的负面危险比为0.50表明该病毒的显着保护作用。在男性中，没有观察到与生存的关联。对于CMV Serostatus和死亡率之间的关系，没有找到CD4：8比的中介效应。具有R> 5的非常老年CMV阴性女性经历了最高的死亡率，与年龄和合并症无关。 CMV Serostatus和CD4：8比率与死亡率的关联似乎反映了在非常旧人类中介导的寿命的明显途径。

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