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首页> 外文期刊>AIDS care. >Health-related quality of life in perinatally HIV-infected children in the Netherlands
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Health-related quality of life in perinatally HIV-infected children in the Netherlands

机译：荷兰围产期感染艾滋病毒的儿童的健康相关生活质量

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摘要

Combination antiretroviral therapy (cART) can alter HIV infection in children into a chronic condition. Studies investigating health-related quality of life (HRQoL) in HIV-infected children are scarce, and lacking from Western Europe. This study aimed to compare the HRQoL of clinically stable perinatally HIV-infected children to healthy, socioeconomically (SES)-matched controls as well as the Dutch norm population, and to explore associations between HIV and cART-related factors with HRQoL. HIV-infected and healthy children aged 8-18 years completed the Pediatric Quality of Life Inventory 4.0 (PedsQL). We determined differences between groups on PedsQL mean scores, and the proportion of children with an impaired HRQoL per group (1 SD lower than the Dutch norm population). Logistic regression models were used to explore associations between disease-related factors and HRQoL impairment. In total, 33 HIV-infected and 37 healthy children were included. There were no differences in the mean PedsQL subscales between HIV-infected children and both control groups. The proportion of children with an impaired HRQoL was higher in the HIV-infected group (27%) as compared to the healthy control group (22%) and the Dutch norm (14%) on the school functioning subscale (HIV vs. Dutch norm: P=.045). Mean scores of HRQoL of perinatally HIV-infected children in the Netherlands were not different from a SES-matched control group, or from the Dutch norm population. However, the HIV-infected group did contain more children with HRQoL impairment, suggesting that HIV-infected children in the Netherlands are still more vulnerable to a compromised HRQoL.
机译：联合抗逆转录病毒疗法（cART）可以将儿童的HIV感染改变为慢性病。在西欧，缺乏研究针对感染了艾滋病毒的儿童的健康相关生活质量（HRQoL）的研究。这项研究旨在比较临床稳定的围产期感染HIV的儿童与健康，社会经济（SES）匹配的对照以及荷兰正常人群的HRQoL，并探讨HIV和cART相关因素与HRQoL之间的关联。 8-18岁的受HIV感染且健康的儿童完成了小儿生活质量调查表4.0（PedsQL）。我们确定了PedsQL平均得分各组之间的差异，以及每组HRQoL受损的儿童比例（比荷兰正常人群低1 SD）。使用逻辑回归模型探讨疾病相关因素与HRQoL损害之间的关联。总共包括33名HIV感染者和37名健康儿童。感染艾滋病毒的儿童与两个对照组之间的平均PedsQL分量表均无差异。在学校功能子量表中，HIV感染组（27％）的HRQoL受损儿童比例高于健康对照组（22％）和荷兰规范（14％）（HIV与荷兰规范） ：P ＝ .045）。在荷兰，围产期感染HIV的儿童的HRQoL的平均得分与SES匹配对照组或荷兰正常人群没有差异。但是，HIV感染组确实包含更多的HRQoL障碍儿童，这表明荷兰的HIV感染儿童仍然更容易受到HRQoL感染。

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