Conservancy of the alpha4beta7 integrin mimotope in the V2 domain of HIV type 1 CRF07_BC compared to subtype B' strains in China.

He X; Mokili JL; Hong K; Chen J; Wei J; Xin R; Song YH; Feng Y; Jia M; Xing H; Shao Y

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Conservancy of the alpha4beta7 integrin mimotope in the V2 domain of HIV type 1 CRF07_BC compared to subtype B' strains in China.

机译：与中国的B'亚型相比，HIV 1型CRF07_BC的V2域中alpha4beta7整合素模拟表位的保守性。

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HIV-1 is capable of mimicking the ligand of integrin alpha(4)beta(7) by displaying a tripeptide mimotope on the V2 region. Through this mimicry HIV can bind the alpha(4)beta(7) integrin and get carried through the lymphocyte proliferation signaling pathway, cell-to-cell adhesion and can migrate to gut-associated lymphoid tissues. The same tripeptide motif was suggested to be the epicenter of neutralization in laboratory strains of HIV-1. In this study, we compared the alpha(4)beta(7) binding sites of two HIV-1 subtypes prevalent in China and found that the tripeptide binding domain of alpha(4)beta(7) was more diverse in subtype B' strains than in CRF07_BC.

机译：HIV-1能够通过在V2区域显示三肽模拟表位来模仿整联蛋白alpha（4）beta（7）的配体。通过这种模仿，HIV可以结合alpha（4）beta（7）整合素，并通过淋巴细胞增殖信号通路，细胞与细胞的粘附而被携带，并可以迁移到肠道相关的淋巴组织。建议在实验室HIV-1病毒中，相同的三肽基元是中和的中心。在这项研究中，我们比较了在中国流行的两种HIV-1亚型的alpha（4）beta（7）结合位点，发现在亚型B'株中，alpha（4）beta（7）的三肽结合域更加多样化比在CRF07_BC中。

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《AIDS Research and Human Retroviruses》 |2011年第10期|共7页
作者
He X; Mokili JL; Hong K; Chen J; Wei J; Xin R; Song YH; Feng Y; Jia M; Xing H; Shao Y;
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正文语种 eng
中图分类传染病;
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1. Conservancy of the alpha4beta7 integrin mimotope in the V2 domain of HIV type 1 CRF07_BC compared to subtype B' strains in China. [J] . He X, Mokili JL, Hong K, AIDS Research and Human Retroviruses . 2011,第10期

机译：与中国的B'亚型相比，HIV 1型CRF07_BC的V2域中alpha4beta7整合素模拟表位的保守性。
2. Near full-length genomic characterization of a novel HIV type 1 subtype B/C recombinant strain from Yunnan, China. [J] . Li L, Chen L, Yang S, AIDS Research and Human Retroviruses . 2010,第6期

机译：来自中国云南的新型HIV 1型B / C亚型重组菌株的近全长基因组学表征。
3. Variability OF HIV-1 V2 env domain for integrin binding: Clinical correlates [J] . Fabrizio Claudia, Bavaro Davide F., Scudeller Luigia, Virology . 2019,第期

机译：联合素结合的HIV-1 V2 ENV结构域的变异性：临床相关性
4. Subtyping Cuban HIV-1 Strains by envHMA [C] . N. Martinez, M. Blanco, H.M. Diaz International AIDS Conference . 2004

机译：亚级古巴HIV-1由envhma菌株
5. The role of the transmembrane and cytoplasmic domains of the VPU protein of human immunodeficiency virus type 1 (HIV-1) in the acute CD4+ T cell loss and disease in the simian human immunodeficiency virus (SHIV)/macaque model. [D] . Hout, David Richard. 2006

机译：人类免疫缺陷病毒1型（HIV-1）的VPU蛋白的跨膜和胞质域在猿猴人类免疫缺陷病毒（SHIV）/猕猴模型的急性CD4 + T细胞丧失和疾病中的作用。
6. Enhanced Fusion and Virion Incorporation for HIV-1 Subtype C Envelope Glycoproteins with Compact V1/V2 Domains [O] . Marielle Cavrois, Jason Neidleman, Mario L. Santiago, 2014

机译：具有紧凑的V1 / V2域的HIV-1 C型亚型包膜糖蛋白的增强融合和病毒体结合。
7. Development of an HIV-1 Subtype Panel in China: Isolation and Characterization of 30 HIV-1 Primary Strains Circulating in China. [O] . Jingwan Han, Siyang Liu, Wei Guo, 2015

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Conservancy of the alpha4beta7 integrin mimotope in the V2 domain of HIV type 1 CRF07_BC compared to subtype B' strains in China.

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