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首页> 外文期刊>AIDS Research and Human Retroviruses >Lipodystrophy and inflammation predict later grip strength in HIV-infected men: The MACS body composition substudy
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Lipodystrophy and inflammation predict later grip strength in HIV-infected men: The MACS body composition substudy

机译：脂肪营养不良和炎症可预测艾滋病毒感染男性的稍后握力：MACS身体成分研究

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Body fat changes in HIV-infected persons are associated with increased systemic inflammation and increased mortality. It is unknown whether lipodystrophy is also associated with declines in physical function. Between 2001 and 2003, 33 HIV-infected men with evidence of lipodystrophy (LIPO +), 23 HIV-infected men without lipodystrophy (LIPO-), and 33 seronegative men were recruited from the Multicenter AIDS Cohort Study (MACS) for the Body Composition substudy. Visceral adipose tissue (VAT) was assessed by quantitative computed tomography. Lean body mass (LBM) and extremity fat were measured by dual-energy x-ray absorptiometry. Insulin resistance was estimated by Homeostatic Model Assessment (HOMA). Serum interleukin (IL)-6, soluble tumor necrosis factor (TNF)-α receptors I and II (sTNFRI and sTNFRII), and highly sensitive C-reactive protein (hs-CRP) concentrations were quantified from archived serum samples. These measurements were correlated with grip strength measured in 2007 using linear regression. At the substudy visit, the LIPO+ group had higher HOMA, sTNFRI, sTNFRII, and IL-6 levels than the LIPO- group. In 2007, the LIPO+ group had lower median grip strength than the LIPO- group (34.4 vs. 42.7 kg, p=0.002). Multivariable analysis of HIV+ men showed older age, lower LBM, higher sTNFRII concentrations, and LIPO+ status [adjusted mean difference -4.9 kg (p=0.045)] at the substudy visit were independently associated with lower subsequent grip strength. Inflammation, lower LBM, and lipodystrophy in HIV-infected men were associated with lower subsequent grip strength. These findings suggest that inflammation may contribute to declines in functional performance, independent of age.
机译：HIV感染者体内的脂肪变化与全身性炎症增加和死亡率增加有关。尚不知道脂肪营养不良是否也与身体机能下降有关。在2001年至2003年之间，从多中心艾滋病队列研究（MACS）中招募了33名有脂代谢障碍（LIPO +）证据的HIV感染男性，23名无脂代谢障碍（LIPO-）的HIV感染男性和33名血清阴性的男性。研究。通过定量计算机体层摄影术评估内脏脂肪组织（VAT）。瘦体重（LBM）和四肢脂肪通过双能X射线吸收法测量。通过稳态模型评估（HOMA）评估胰岛素抵抗。从归档的血清样品中定量测定血清白介素（IL）-6，可溶性肿瘤坏死因子（TNF）-α受体I和II（sTNFRI和sTNFRII）以及高敏感性C反应蛋白（hs-CRP）的浓度。这些测量值与2007年使用线性回归测得的握力强度相关。在子研究访问中，LIPO +组的HOMA，sTNFRI，sTNFRII和IL-6水平高于LIPO-组。 2007年，LIPO +组的中位握力低于LIPO-组（34.4 vs. 42.7 kg，p = 0.002）。对HIV +男性的多变量分析显示，在本次研究访视时，年龄较大，LBM较低，sTNFRII浓度较高和LIPO +状态[校正后平均差异-4.9 kg（p = 0.045）]与随后的较低握力独立相关。 HIV感染男性的发炎，较低的LBM和脂肪营养不良与随后的握力降低有关。这些发现表明，炎症可能与年龄无关，导致功能下降。

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