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首页> 外文期刊>Biotechnology Progress >Baculovirus P35 Protein: An Overview of its Applications Across Multiple Therapeutic and Biotechnological Arenas
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Baculovirus P35 Protein: An Overview of its Applications Across Multiple Therapeutic and Biotechnological Arenas

机译：杆状病毒P35蛋白：其在多种治疗和生物技术领域的应用概述

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Baculovirus immediate early P35 protein is well known for its anti-apoptotic as well as anti-oxidant properties. Mechanism of action of P35 involves inhibition of a vast range of initiator to executioner class of caspases. In addition, P35's role in inhibiting oxidant-induced mitochondrial damage, primarily in the apoptotic pathway, has also been extensively investigated. Elucidation of P35's functions during regulation of programmed cell death (PCD) has led to a renewed focus on exploiting this basic knowledge for clinical and other related applications. This review outlines specific biochemical and genetic pathways where P35 intervenes and regulates rate-limiting steps in the apoptotic signaling cascade. Research efforts are underway to utilize P35 as an agent in regulating apoptosis and under certain circumstances, also explore the therapeutic potential of its anti-oxidant features. One of the major outcomes of recent studies include significantly improved effectiveness of cytochrome P450 directed enzyme pro-drug delivery tools when used in conjunction with P35, which may help in alleviating drug resistance in tumor cells and simultaneously prolonging the cytotoxic effects of anti-cancer drugs. Moreover, applied research carried out recently in the fields of diabetes, ischemia-induced neuronal cell death, experimental autoimmune encephalomyelitis (EAE), multiple sclerosis (MS), inflammatory arthritis, cardiovascular and ocular disorders illustrate P35's utilization across diverse therapeutic areas and will certainly make it an attractive biomolecule for the discovery research.
机译：杆状病毒即刻早期P35蛋白以其抗凋亡和抗氧化特性而闻名。 P35的作用机制涉及抑制大范围的启动子到执行酶类的胱天蛋白酶。此外，还广泛研究了P35在抑制氧化剂引起的线粒体损伤（主要在细胞凋亡途径中）中的作用。对P35在程序性细胞死亡（PCD）调节过程中的功能的阐明，导致人们重新关注将这一基本知识用于临床和其他相关应用。这篇综述概述了P35干预并调节凋亡信号级联反应中的限速步骤的特定生化和遗传途径。目前正在开展研究工作，以利用P35作为调节细胞凋亡的药物，并在某些情况下还探索其抗氧化功能的治疗潜力。近期研究的主要成果之一是，与P35结合使用时，细胞色素P450定向酶前药递送工具的有效性显着提高，这可能有助于减轻肿瘤细胞的耐药性，同时延长抗癌药物的细胞毒性作用。此外，最近在糖尿病，局部缺血引起的神经元细胞死亡，实验性自身免疫性脑脊髓炎（EAE），多发性硬化症（MS），炎性关节炎，心血管疾病和眼部疾病等领域进行的应用研究表明P35在不同治疗领域的应用，并且一定会使它成为发现研究的诱人生物分子。

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