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首页> 外文期刊>Alcohol >Effect of gestational ethanol exposure on long-term memory formation in newborn chicks.
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Effect of gestational ethanol exposure on long-term memory formation in newborn chicks.

机译：妊娠期乙醇暴露对新生雏鸡长期记忆形成的影响。

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Fetal alcohol syndrome (FAS), a condition occurring in some children of mothers who have consumed alcohol during pregnancy, is characterized by craniofacial malformations, and physical and mental retardation. It is significant that even children with history of gestational ethanol exposure but relatively unaffected overall IQ performance, often exhibit learning difficulties and behavioral problems, suggestive of impaired memory formation. Hence, the specific aim of this study was to examine memory formation in chicks exposed to ethanol during early gestation toward the understanding of neurobehavioral disturbances in FAS. Chicks were exposed to alcohol on gestational days 1-3 by injection of ethanol into the airspace of freshly fertilized eggs. The effects of prenatal ethanol on physical growth and development, and memory formation were studied. The one-trial passive avoidance learning paradigm in 1-day-old chicks was used to study memory formation in these chicks. It was observed that chick embryos exposed to 10% ethanol on gestational days 1-3 had significant reduction in all body parameters when compared with appropriate controls. Further, ethanol-exposed chick embryos had significantly impaired (P<.05) long-term memory (LTM) formation after training, though short-term or intermediate-term memory formation was unimpaired. Thus, the findings of the current study demonstrate the detrimental effects of ethanol exposure during early pregnancy on developing chick embryos in general and on memory formation in particular. Hence, it is suggested that impairment in LTM could be a fundamental mechanism for learning disorders and neurobehavioral abnormalities observed in FAS.
机译：胎儿酒精综合症（FAS）是一种在怀孕期间饮酒的母亲的某些儿童中发生的疾病，其特征是颅面畸形以及身心发育迟缓。值得注意的是，即使有妊娠乙醇暴露史但总体智商表现相对未受影响的儿童，也经常出现学习困难和行为问题，提示记忆力形成受损。因此，这项研究的具体目的是检查妊娠早期暴露于乙醇的雏鸡的记忆形成，以了解FAS中的神经行为障碍。在妊娠第1-3天，通过将乙醇注射到新鲜受精卵的空域中，使小鸡接触酒精。研究了产前乙醇对身体生长发育和记忆形成的影响。 1天大的雏鸡的一次试验性被动回避学习范例用于研究这些雏鸡的记忆形成。观察到，与适当的对照相比，在妊娠第1-3天暴露于10％乙醇的雏鸡胚胎的所有身体参数均明显降低。此外，尽管短期或中期记忆形成没有受到损害，但暴露于乙醇的雏鸡胚胎在训练后已大大削弱了（P <.05）长期记忆（LTM）的形成。因此，本研究的结果表明，怀孕初期乙醇暴露对发育中的雏鸡胚胎特别是记忆形成的有害影响。因此，建议LTM的损伤可能是FAS中观察到的学习障碍和神经行为异常的基本机制。

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