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首页> 外文期刊>AJRI: American Journal of Reproductive Immunology >Interactions of HIV, other sexually transmitted diseases, and genital tract inflammation facilitating local pathogen transmission and acquisition.
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Interactions of HIV, other sexually transmitted diseases, and genital tract inflammation facilitating local pathogen transmission and acquisition.

机译:HIV,其他性传播疾病和生殖道炎症的相互作用促进了局部病原体的传播和获取。

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摘要

Despite several decades of clinical trials assessing the impact of etiological treatment of sexually transmitted diseases (STDs) to decrease HIV acquisition and transmission, almost all of these trials have not proven to be efficacious. Increasing evidence suggests that specific STD treatment alone may not be sufficient to alter the genital tract inflammatory milieu that is created by STDs. This paper examines the associations between STDs and HIV susceptibility and infectiousness, and considers the role of chronic and refractory inflammation to create an environment that potentiates HIV and STD transmission and acquisition by reviewing biological, observational, and clinical trial data.
机译:尽管数十年来的临床试验评估了性传播疾病(STDs)的病因治疗对减少HIV感染和传播的影响,但几乎所有这些试验都没有被证明是有效的。越来越多的证据表明,单独的特殊性病治疗可能不足以改变性病引起的生殖道炎性环境。本文研究了性传播疾病与艾滋病毒易感性和传染性之间的联系,并通过审查生物学,观察和临床试验数据,考虑了慢性和难治性炎症在创造有利于艾滋病毒和性病传播和获取的环境中的作用。

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