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首页> 外文期刊>DNA and Cell Biology >Location, location, location! Monotremes provide unique insights into the evolution of sex chromosome silencing in mammals
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Location, location, location! Monotremes provide unique insights into the evolution of sex chromosome silencing in mammals

机译:位置,位置,位置! MONOTREMES在哺乳动物中沉默的沉默沉默的演变提供了独特的见解

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摘要

Platypus and echidnas are the only living representative of the egg-laying mammals that diverged 166 million years ago from the mammalian lineage. Despite occupying a key spot in mammalian phylogeny, research on monotremes has been limited by access to material and lack of molecular genetic resources. This has changed recently, and the sequencing of the platypus genome has promoted monotremes into a generally accessible tool in comparative genomics. The most extraordinary aspect of the monotreme genome is an amazingly complex sex chromosomes system that shares extensive homology with bird sex chromosomes and no homology with sex chromosomes of other mammals. This raises important questions about dosage compensation of the five pairs of sex chromosomes in females and meiotic silencing in males, and we are only beginning to unravel possible mechanisms and pathways that may be involved. The homology between monotreme and bird sex chromosomes makes comparison between those species worthwhile, also as they provide a well-defined example where the same sex chromosomes changed from female heterogamety (chicken) to male heterogamety (monotremes). We summarize recent research on monotreme and chicken sex chromosomes and discuss possible mechanisms that may contribute to sex chromosome silencing in monotremes.
机译:鸭嘴兽和echidnas是蛋置哺乳动物的唯一生活,这些乳房哺乳动物来自哺乳动物血统的16600万年。尽管占据了哺乳动物的关键点,但对单调的研究受到物质和缺乏分子遗传资源的限制。这最近发生了变化,鸭嘴兽基因组的测序促进了比较基因组学中一般可接近的工具中的单调。 MONOTREME Genome最常见的方面是一种惊人的性染色体系统,与禽类性染色体分享广泛的同源性,没有其他哺乳动物的性染色体的同源性。这提出了关于雌性女性和减数分裂沉默的五对性染色体的剂量补偿的重要问题,我们只开始解析可能涉及的可能机制和途径。单调和鸟类性染色体之间的同源性,也是价值的那些物种之间的比较,因为它们提供了一种明确的例子,其中相同的性染色体从女性异染(鸡肉)变为男性异源性(MONOTREMES)。我们概述了最近关于单调和鸡肉性染色体的研究,并讨论可能有助于性染色体在单调中染色的可能机制。

著录项

  • 来源
    《DNA and Cell Biology》 |2009年第2期|共10页
  • 作者

    Daish T; Grutzner F;

  • 作者单位

    Discipline of Genetics School of Molecular and Biomedical Science The University of Adelaide Adelaide Australia .;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物化学;
  • 关键词

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