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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vivo biocompatibility, vascularization, and incorporation of Integra((R)) dermal regenerative template and flowable wound matrix
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In vivo biocompatibility, vascularization, and incorporation of Integra((R)) dermal regenerative template and flowable wound matrix

机译：在体内生物相容性，血管化和掺入Integra（（R））皮肤再生模板和可流动伤口基质

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摘要

Integra((R)) matrix wound dressing (MWD) is used for the reconstruction of full-thickness skin defects. For the treatment of complex wounds, this dermal substitute is available as a flowable wound matrix (FWM) of identical composition. To clarify whether variations in sample preparation and consistency affect the biocompatibility and tissue incorporation, we herein compared MWD and FWM. The matrices were characterized using scanning electron microscopy and histology. Moreover, they were implanted in mouse dorsal skinfold chambers to analyze their in vivo performance over 2 weeks. Scanning electron microscopy showed a planar surface of MWD whereas FWM presented an irregular, fissured morphology. However, histology of the two matrices revealed an identical fiber thickness, fiber length, and interfiber distance. Repetitive stereo-microscopy and immunohistochemical analyses of MWD and FWM showed a comparable epithelialization of the implants in the dorsal skinfold chamber model. At day 14, both matrices exhibited a low collagen content and microvessel density. Moreover, they were infiltrated by a high number of myeloperoxidase (MPO)-positive neutrophilic granulocytes and a lower number of MAC387-positive macrophages and CD3-positive lymphocytes. These findings demonstrate that differences in preparation and consistency do not affect the tissue response to MWD and FWM, indicating a comparable regenerative capacity in wound healing. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 52-60, 2018.
机译：Integra（（R））基质伤口敷料（MWD）用于重建全厚皮肤缺陷。为了处理复杂伤口，这种皮肤替代品可作为相同组成的可流动伤口基质（FWM）。为了阐明样品制备和一致性的变化是否影响了生物相容性和组织掺入，我们在此比较了MWD和FWM。使用扫描电子显微镜和组织学表征基质。此外，它们植入小鼠背部贴片室，以分析其体内性能超过2周。扫描电子显微镜显示MWD的平面表面，而FWM呈现不规则，裂纹的形态。然而，两个矩阵的组织学揭示了相同的纤维厚度，纤维长度和纤维距离。 MWD和FWM的重复立体显微镜和免疫组织化学分析显示了背部肤质腔室模型中植入物的可比上皮。在第14天，两种基质表现出低胶原含量和微血管密度。此外，它们被大量髓过氧化酶（MPO） - 阳性中性粒细胞和较少数量的MAC387阳性巨噬细胞和CD3阳性淋巴细胞渗透。这些研究结果表明，制备和一致性的差异不会影响对MWD和FWM的组织反应，表明伤口愈合的可比再生能力。 （c）2016 Wiley期刊，Inc。J生物密制Res B部分：Appl Biomater，106B：52-60,2018。

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