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首页> 外文期刊>Journal of biomedical materials research. Part B, Applied biomaterials. >In vitro and in vivo study of commercial calcium phosphate cement HydroSet (TM)
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In vitro and in vivo study of commercial calcium phosphate cement HydroSet (TM)

机译：体外和体内磷酸钙水泥水泥加氢机（TM）的研究

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The commercial calcium phosphate cement, HydroSet, was investigated in vitro, studying phase formation, compressive strength and setting time, followed by an ovine in vivo study to measure osseointegration, bone apposition and bone-to-graft contact. The X-ray diffraction and P-31 Magic Angle Spinning Nuclear Magnetic Resonance (MAS NMR) results showed the initial formation of octacalcium phosphate and hydroxyapatite at one hour. Over 7 days the octacalcium phosphate transformed to apatite, which was the only crystalline phase of the cement at 28 days. This apatite phase is thought to be a calcium deficient apatite. In the scanning electron microscopy, histological images of 12-week ovine in vivo results showed a high degree of osseointegration, 92.5%. Compressive strength comparisons between in vitro and in vivo measurements showed a dramatic difference between the in vitro measurements (highest 25.4 MPa) and in vivo (95 MPa), attributed to bone ingrowth into the cement in vivo. To the best of our knowledge this is the first time phase evolution of HydroSet and the properties studied in vitro complement the in vivo evaluation of the cement in a publication. The significance of the new finding of initial formation of octacalcium phosphate in this cement is discussed. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 21-30, 2018.
机译：在体外研究了商业磷酸钙水泥，水泥，研究相，压缩强度和设定时间，然后在体内研究中进行绵羊，以测量骨整合，骨相和骨对移植接触。 X射线衍射和P-31魔角纺丝核磁共振（MAS NMR）结果显示初始形成磷酸钙和羟基磷灰石的初始形成。超过7天的磷酸叔钙转化为磷灰石，这是水泥的唯一晶相28天。这种磷灰石相被认为是缺乏缺乏的磷灰石。在扫描电子显微镜中，体内烯的12周烯的组织学图像显示出高度的骨整合程度，92.5％。体外和体内测量之间的抗压强度比较显示了体外测量（最高25.4MPa）和体内（95MPa）之间的显着差异，归因于体内水泥的水泥。据我们所知，这是Hydraset的第一次阶段演变和在体外研究的性质补充了在出版物中的水泥的体内评价。讨论了在该水泥中初始形成初始形成初始形成的重要性。 （c）2016年Wiley期刊，Inc。J生物保解员B：苹果生物摩特，106B：21-30,2018。

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