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首页> 外文期刊>Advances in anatomy embryology and cell biology. >The Pattern of Cortical Lesions in Preclinical Stages
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The Pattern of Cortical Lesions in Preclinical Stages

机译：临床前期皮质病变的模式

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As the pathological process progresses and secondary to the subcortical lesions described above, abnormal tau aggregates appear for the first time in the cerebral cortex generally in the transentorhinal region. AT8-ir lesions are present in neuro-nal processes, most probably in terminal portions of axons, and we designate such cases as having "cortical stage la" tau pathology (Table 2.1; Figs. 7.1 and 7.2). The predominantly radially aligned thread-like cellular processes are easier to see in unconventionally thick sections (Fig. 7.1a, b). A thin network of finely shaped and weakly AT8-ir neuronal processes (axons) together with more intensely immunostained dots develops. Sometimes, however, it is possible to follow several of the processes over longer distances, and they often end with a droplet-like swelling (Figs. 7. lc, d and 7.2a). All stage la cases show the presence of subcortical tau lesions resembling those found in stages a-c (see Sects. 5.1 and 5.2).
机译：随着病理过程的发展并继发于上述皮下皮下病变，异常的tau聚集物通常在整个横肠小肠区域首次出现在大脑皮层中。 AT8-ir损伤存在于神经元过程中，最有可能在轴突的末端部分，我们将这种情况指定为具有“皮质期la” tau病理（表2.1;图7.1和7.2）。在非常规的厚截面中，主要是沿径向排列的线状细胞过程更容易看到（图7.1a，b）。会形成一个细小且形状较薄的AT8-ir神经元过程（轴突）以及更强烈的免疫染色点网络。但是，有时可能会在更长的距离上遵循多个过程，并且它们通常以液滴状的膨胀结束（图7.lc，d和7.2a）。所有1a期病例都显示出类似于a-c期的皮层下tau病变（见5.1和5.2节）。

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