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首页> 外文期刊>Journal of Nutritional Science and Vitaminology >Effect of Ovariectomy and Ovarian Hormone Administration on Hepatic Autophagy in Female Rats
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Effect of Ovariectomy and Ovarian Hormone Administration on Hepatic Autophagy in Female Rats

机译：卵巢切除术和卵巢激素给药对雌性大鼠肝自噬的影响

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摘要

Autophagy is a major intracellular proteolytic process that contributes to the maintenance of protein homeostasis. Recent studies reported the induction of autophagy in the uterus and proximal tibias of ovariectomized (OVX) rodents, which was blocked by the injection of ovarian hormones. However, whether OVX and ovarian hormone treatment can regulate autophagy in the liver has not been clarified. Recently, it was revealed that autophagy is closely involved in hepatic lipid metabolism. The purpose of this study was to investigate the influence of OVX on autophagy in the rat liver as a first step to clarify the relationship between hepatic fat accumulation and the change in autophagy caused by OVX. We found that hepatic autophagy tended to be lower in OVX rats than in sham-operated rats. In addition, hepatic autophagy in OVX rats was induced by short-term exposure to ovarian hormones, especially progesterone. This study suggests that autophagy in the rat liver is suppressed by OVX and activated by progesterone. However, the autophagy-promoting effect of beta-estradiol was not clarified.
机译：自噬是一种主要的细胞内蛋白水解过程，有助于维持蛋白质稳态。最近的研究报告说，卵巢切除（OVX）啮齿动物的子宫和近端胫骨诱导卵巢，其被卵巢激素的注射阻断。然而，OVX和卵巢激素治疗是否可以调节肝脏中的自噬尚未澄清。最近，据透露，自噬密切参与肝脂质代谢。本研究的目的是研究OVX在大鼠肝脏上自噬的影响作为澄清肝脂肪积累与OVX引起的自噬关系的第一步。我们发现肝自噬倾向于OVX大鼠比假手术大鼠降低。此外，通过短期暴露于卵巢激素，尤其是黄体酮的短期暴露诱导ovx大鼠肝自血病。该研究表明，通过ovx抑制了大鼠肝脏中的自噬并用孕酮激活。然而，β-雌二醇的自噬促进效果未澄清。

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