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首页> 外文期刊>American journal of clinical pathology. >Frequent positive staining with NKI/C3 in normal and neoplastic tissues limits its usefulness in the diagnosis of cellular neurothekeoma.
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Frequent positive staining with NKI/C3 in normal and neoplastic tissues limits its usefulness in the diagnosis of cellular neurothekeoma.

机译：正常和赘生性组织中经常用NKI / C3阳性染色限制了其在诊断细胞神经鞘瘤中的用途。

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摘要

NKI/C3 originally was described as a marker for melanoma. Recently, it resurfaced as a marker to separate cellular neurothekeoma from other dermal tumors in the differential diagnosis. To determine the sensitivity and specificity of NKI/C3, we evaluated its staining pattern in 709 normal and neoplastic tissues, including 92 dermal tumors, using tissue microarrays and conventional sections. We found that although NKI/C3 is positive in only a few normal tissues, it stains a broad spectrum of neoplastic tissues. NKI/C3 is also positive in many dermal tumors of possible histiocytic origin, including juvenile xanthogranuloma (6/10), atypical fibroxanthoma (4/12), cellular fibrous histiocytoma (5/10), reticulohistiocytoma (3/6), and xanthoma (8/10). However, it is negative in epithelioid cell histiocytomas (0/7) and Langerhans cell histiocytosis (0/9). Given the wide spectrum of positive staining in morphologic mimics of cellular neurothekeomas, pathologists should be cautious when making this diagnosis based solely on positive staining with NKI/C3.
机译：NKI / C3最初被描述为黑色素瘤的标志物。最近，在鉴别诊断中，它重新成为一种标志物，以将细胞性神经鞘瘤与其他皮肤肿瘤区分开。为了确定NKI / C3的敏感性和特异性，我们使用组织芯片和常规切片评估了其在709例正常和赘生性组织（包括92个皮肤肿瘤）中的染色模式。我们发现，尽管NKI / C3仅在少数正常组织中呈阳性，但它会染色广谱的肿瘤组织。 NKI / C3在许多可能具有组织细胞起源的皮肤肿瘤中也呈阳性，包括少年黄原肉芽肿瘤（6/10），非典型纤维黄瘤（4/12），细胞性纤维组织细胞瘤（5/10），网状组织细胞瘤（3/6）和黄瘤（8/10）。然而，在上皮样细胞组织细胞瘤（0/7）和朗格汉斯细胞组织细胞增生（0/9）中为阴性。鉴于细胞神经鞘瘤的形态学模拟中存在广泛的阳性染色，病理学家在仅基于NKI / C3阳性染色进行诊断时应谨慎。

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