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首页> 外文期刊>Journal of radiation oncology >Multilesion glioblastoma multiforme in the modern chemo-radiotherapy era: an analysis of pattern of failure and overall survival
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Multilesion glioblastoma multiforme in the modern chemo-radiotherapy era: an analysis of pattern of failure and overall survival

机译：现代化化疗中的多形胶质母细胞瘤多形体：失败模式和整体生存模式分析

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Purpose/objectives We sought to evaluate the pattern of disease progression and survival of patients with multilesion glioblastoma (GBM) in a modern patient cohort. Methods/materials We retrospectively collected the clinical data of patients over 2004-2014 with newly diagnosed GBM. Following resection (or biopsy), all patients received radiotherapy to 60 Gy in 30 fractions with concurrent and adjuvant temozolomide. Preoperative MRIs were reviewed by a single diagnostic radiologist blinded to treatment outcomes and categorized as single focus or multilesion (multifocal/multicentric). Multifocal tumors were defined as noncontiguous enhancement along known neural pathways and multicentric tumors were defined as noncontiguous enhancement along disjointed pathways (i.e., different lobes). Univariate and multivariate (MVA) analyses were performed to investigate factors prognostic of overall survival. Results Of 155 eligible patients, 30 presented with a multilesion tumor focus (19.4%). Of the patients that developed recurrent disease before death in - 123), the predominant pattern of failure was local (80%) and did not differ by focality (p = 0.18). Unifocal, multifocal, and multicentric tumors demonstrated similar actuarial disease progression (p = 0.12).
机译：我们试图评估现代患者队列中多次胶质母细胞瘤（GBM）疾病进展和存活的目的/目标。方法/材料我们回顾性地收集了2004 - 2014年患者的临床资料，新诊断为GBM。在切除（或活检）之后，所有患者均在30分级分中接受放射治疗，并与同时和佐剂替替莫唑胺。术前MRI通过蒙蔽到治疗结果的单一诊断放射科医生，并作为单一焦点或多次（多焦点/多中心）进行分类。多灶性肿瘤被定义为沿着已知的神经途径的非连续增强，并且多中心肿瘤被定义为沿脱节途径（即，不同的裂片）的非连续增强。进行单变量和多变量（MVA）分析，以调查总体存活的因素。结果155名符合条件的患者，30名患有多人肿瘤重点（19.4％）。在-123之前发育复发性疾病的患者的患者，失败的主要模式是局部（80％），并且没有焦点不同（p = 0.18）。 Unifocal，多焦点和多中心肿瘤表现出类似的致剂疾病进展（p = 0.12）。

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