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首页> 外文期刊>Journal of Veterinary Research >Serum paraoxonase as an indicator for fatty liver in sheep
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Serum paraoxonase as an indicator for fatty liver in sheep

机译：血清律催化酶作为羊脂肪肝脏的指标

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摘要

Introduction: A model of fatty liver in postpartum sheep was established to measure blood paraoxonase 1 (PON1) and other biochemical indicators, which were used to predict fatty liver in sheep. Material and Methods: Sheep were assigned into two experimental groups: a fatty liver group (T, n = 10) and a healthy control group (C, n = 5). PON1 enzyme activity towards paraoxon as a substrate was quantified spectrophotometrically. The results were analysed by t-test and pearson correlation coefficient. Disease was predicted by binary logistic analysis, and diagnostic thresholds were determined by receiver operatingcharacteristic (ROC) analysis. Results: The activity of serum PON1 in group T was significantly decreased (P 0.05) when compared with C group, and liver lipid content and the levels of serum BHBA, NEFA, and TG were significantly increased (P 0.05). Thresholds were lower than 74.0 U/mL for PON1, higher than 0.97 mmol/L for beta-hydroxybutyrate, higher than 1.29 mmol/L for non-esterified fatty acids, higher than 0.24 mmol/L for triglycerides, and lower than 71.35 g/L for total protein. Conclusion: This study verified that PON1, BHBA, NEFA, TG, and TP could be used to predict the risk of fatty liver in sheep.
机译：介绍：制定了产后羊脂肪肝模型，以测量血脂酰亚膦酶1（PON1）和其他生化指标，用于预测绵羊的脂肪肝。材料和方法：分配到两种实验组：脂肪肝组（T，N = 10）和健康对照组（C，N = 5）。将PON1酶活性朝向糖酮作为底物定量分光光度法。通过T检验和Pearson相关系数分析结果。通过二进制物流分析预测疾病，通过接收器操作特征（ROC）分析确定诊断阈值。结果：与C组相比，T组T组血清PON1的活性显着降低（P <0.05），肝脂质含量和血清BHBA，NEFA和TG的水平显着增加（P <0.05）。 PON1的阈值低于74.0u / ml，对于β-羟基丁酸酯，高于0.97mmol / L，对于非酯化脂肪酸，高于1.29mmol / L，对于甘油三酯，高于0.24mmol / L，低于71.35g / l总蛋白质。结论：本研究核实PON1，BHBA，NEFA，TG和TP可用于预测绵羊脂肪肝的风险。

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  • 来源
    《Journal of Veterinary Research》 |2017年第1期|共6页
  • 作者

    Cao Yu; Zhang Jiang; Yang Wei; Xia Cheng; Zhang Hong-You; Wang Yan-Hui; Xu Chuang;

  • 作者单位

    Heilongjiang Bayi Agr Univ Dept Coll Anim Sci &

    Vet Med Daqing 163319 Peoples R China;

    Heilongjiang Bayi Agr Univ Dept Coll Anim Sci &

    Vet Med Daqing 163319 Peoples R China;

    Heilongjiang Bayi Agr Univ Dept Coll Anim Sci &

    Vet Med Daqing 163319 Peoples R China;

    Heilongjiang Bayi Agr Univ Dept Coll Anim Sci &

    Vet Med Daqing 163319 Peoples R China;

    Heilongjiang Bayi Agr Univ Dept Coll Anim Sci &

    Vet Med Daqing 163319 Peoples R China;

    Heilongjiang Bayi Agr Univ Dept Coll Anim Sci &

    Vet Med Daqing 163319 Peoples R China;

    Heilongjiang Bayi Agr Univ Dept Coll Anim Sci &

    Vet Med Daqing 163319 Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 动物医学（兽医学）;
  • 关键词

    sheep; fatty liver; paraoxonase 1; biochemical indices;

    机译：羊;脂肪肝;律氧基酶1;生化指数;

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