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首页> 外文期刊>Journal of cellular biochemistry. >Therapeutic potency of oncolytic virotherapy–induced cancer stem cells targeting in brain tumors, current status, and perspectives
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Therapeutic potency of oncolytic virotherapy–induced cancer stem cells targeting in brain tumors, current status, and perspectives

机译:在脑肿瘤,当前状态和观点靶向靶向病毒治疗诱导的癌症干细胞的治疗效力

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摘要

Abstract Brain tumors are the most common form of solid tumors in children and is presently a serious therapeutic challenge worldwide. Traditional treatment with chemotherapy and radiotherapy was shown to be unsuccessful in targeting brain tumor cancer stem cells (CSCs), leading to recurrent, treatment‐resistant secondary malignancies. Oncolytic virotherapy (OV) is an effective antitumor therapeutic strategy which offers a novel, targeted approach for eradicating pediatric brain tumor CSCs by utilizing mechanisms of cell killing that differ from conventional therapies. A number of studies and some clinical trials have therefore investigated the effects of combined therapy of radiations or chemotherapies with oncolytic viruses which provide new insights regarding the effectiveness and improvement of treatment responses for brain cancer patients. This review summarizes the current knowledge of the therapeutic potency of OVs‐induced CSCs targeting in the treatment of brain tumors for a better understanding and hence a better management of this disease.
机译:摘要脑肿瘤是儿童中最常见的实体瘤形式,目前是全世界严重的治疗挑战。在靶向脑肿瘤癌干细胞(CSCs)中显示出具有化疗和放射疗法的传统治疗,导致反复性,治疗耐药性次要的次要恶性肿瘤。溶瘤病毒治疗(OV)是一种有效的抗肿瘤治疗策略,其通过利用与常规疗法不同的细胞杀伤机制来消除小儿脑肿瘤CSC的新型靶向方法。因此,许多研究和一些临床试验研究了辐射治疗的辐射或化学疗法与肉瘤病毒的影响,为脑癌患者的治疗反应的有效性和改善提供了新的见解。本综述总结了目前对靶向CSCs治疗脑肿瘤的治疗效力的目前的知识,以便更好地理解,从而更好地管理这种疾病。

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