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首页> 外文期刊>Allergy >Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship.
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Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship.

机译：血清25-羟基维生素D和IgE-显着但非线性的关系。

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BACKGROUND: Hormonal vitamin D system affects the determination of T-cell responses. It is unknown if there is an association between vitamin D status and allergic conditions. Our aim was to investigate differences in serum IgE concentrations by vitamin D status [measured by 25(OH)D] and by a genetic variation in a key vitamin D activation enzyme (CYP27B1) previously shown to be associated with type 1 diabetes. METHODS: 9377 participants in the 1958 British birth cohort completed a biomedical assessment at 45 years of age ; 7288 eligible participants had data on 25(OH)D and IgE, with 6429 having further information on CYP27B1 genotype ()1260C>A). RESULTS: There was a nonlinear association between 25(OH)D and IgE (P-value for curvature = 0.0001). Compared with the reference group with the lowest IgE concentrations [25(OH)D 100-125 nmol/l], IgE concentrations were 29% higher (95% CI 9-48%) for participants with the 25(OH)D <25 nmol/l, and 56% higher (95% CI 17-95%) for participants with 25(OH)D >135 nmol/l (adjusted for sex, month, smoking, alcohol consumption, time spent outside, geographical location, social class, PC/TV time, physical activity, body mass index and waist circumference). CYP27B1 genotype was associated with both 25(OH)D (difference for A vs. C allele: 1.88%, 95% CI 0.37-3.4%, P = 0.01) and IgE concentrations ()6.59%, )11.6% to )1.42%, P = 0.01). CONCLUSIONS: These data suggest that there may be a threshold effect with both low and high 25(OH)D levels associated with elevated IgE concentrations. The same CYP27B1 allele that is protective of diabetes was associated with increased IgE concentrations.
机译：背景：激素维生素D系统影响T细胞反应的确定。维生素D状态与过敏状况之间是否存在关联尚不清楚。我们的目的是研究通过维生素D状态（通过25（OH）D测量）和先前显示与1型糖尿病相关的关键维生素D激活酶（CYP27B1）的遗传变异来检测血清IgE浓度的差异。方法：1958年英国出生队列中的9377名参与者在45岁时完成了一项生物医学评估。 7288名符合条件的参与者具有25（OH）D和IgE的数据，其中6429名具有有关CYP27B1基因型（）1260C> A的进一步信息。结果：25（OH）D与IgE之间存在非线性关联（曲率的P值= 0.0001）。与具有最低IgE浓度的参比组[25（OH）D 100-125 nmol / l]相比，25（OH）D <25的参与者的IgE浓度高29％（95％CI 9-48％） nmol / l，对于25（OH）D> 135 nmol / l（针对性别，月份，吸烟，饮酒，在外度过的时间，地理位置，社交环境进行了调整）的参与者，则提高了56％（95％CI 17-95％）课，PC / TV时间，体育锻炼，体重指数和腰围）。 CYP27B1基因型与25（OH）D相关（A与C等位基因差异：1.88％，95％CI 0.37-3.4％，P = 0.01）和IgE浓度（）6.59％，（11.6％至）1.42％ ，P = 0.01）。结论：这些数据表明，低和高25（OH）D水平与升高的IgE浓度相关可能有阈值作用。保护糖尿病的同一CYP27B1等位基因与IgE浓度升高相关。

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