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首页> 外文期刊>Current therapeutic research, clinical and experimental. >The Effect of Iloprost on Renal Function in Patients with Critical Limb Ischemia
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The Effect of Iloprost on Renal Function in Patients with Critical Limb Ischemia

机译：伊洛前列素对危重肢体缺血患者肾功能的影响

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Background: Iloprast, which has efficacy in the microvascular space, is shown to have beneficial effects on the kidney, which has an extensive microvascular network.Objective: We aimed to evaluate the effect of iloprost treatment on kidney functions in patients with critical limb ischemia.Methods: Forty-eight patients with critical limb ischemia who were not suitable for revascularization and who were treated with iloprost were evaluated prospectively in our clinic between September 2010 and December 2012. The patients were divided into 2 groups as patients with chronic renal dysfunction (Group I) and patients with normal renal function (Group II). Urine albuminxreatinine ratio and glomerular filtration rate (GFR) calculated using serum creatinine and serurn cystatin C (GFRcyJ were used to establish the presence of renal dysfunction. The decrease analgesic requirement, walking distance, reduction in ulcer diameter, the increase in ankle-brachial index, and changes in The Society of Vascular Surgery/International Society of Cardiovascular Surgery criteria were used in the evaluation of treatment response.Results: Opioid analgesic requirement and decubitus pain disappeared after treatment in 58.3% (n = 28) of subjects. Walking distance increased in 66.6% (n = 32). Iloprost treatment significantly increased ankle-brachial index (P < 0.01). In Group I the levels of serum urea, creatinine, and cystatin C significantly decreased (P < 0.05), whereas GFRq,c and GFR calculated using the equation of the Chronic Kidney Disease Epidemiology Collaboration (ie, GFR expressed for specified race, sex, and serum creatinine in milligrams per deciliter) was increased significantly compared with pretreatment levels (P < 0.05). No significant change was observed in urine albumin:creatinine ratio (P > 0.05). Conclusions: The use of iloprost in critical limb ischemia can slow down the progress of early stage renal damage. GFRryc and cystatin C, which are indicators of early stage chronic renal dysfunction, can be used for the evaluation of treatment response.
机译：背景：伊洛司特在微血管空间具有疗效，被证明对肾脏具有有益的作用，肾脏具有广泛的微血管网络。目的：我们旨在评估伊洛前列素治疗对严重肢体缺血患者肾脏功能的影响。方法：2010年9月至2012年12月在我院门诊对48例不适合血管重建并接受伊洛前列素治疗的重症肢体缺血患者进行评估。将患者分为两组，即慢性肾功能不全患者（组I）和肾功能正常的患者（第二组）。用血清肌酐和血清胱抑素C（GFRcyJ）计算的尿白蛋白和血浆肾上腺素含量和肾小球滤过率（GFR）用于确定肾功能不全的存在，减少镇痛需要量，步行距离，减少溃疡直径，增加踝肱指数结果：58.2％（n = 28）的受试者在治疗后消失了阿片类镇痛剂和褥疮疼痛，步行距离增加了66.6％（n = 32）。伊洛前列素治疗显着增加了踝肱指数（P <0.01）。在第一组中，血清尿素，肌酐和胱抑素C的水平显着下降（P <0.05），而GFRq，c和使用慢性肾脏病流行病学合作方程式计算的GFR（即，针对特定种族，性别和血清肌酐的GFR表示为毫克/分位数与预处理水平相比，显着增加（P <0.05）。尿白蛋白：肌酐比值未见明显变化（P> 0.05）。结论：伊洛前列素用于危重肢体缺血可减慢早期肾脏损害的进程。 GFRryc和胱抑素C是早期慢性肾功能不全的指标，可用于评估治疗反应。

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