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首页> 外文期刊>Current therapeutic research, clinical and experimental. >Effects of Intraperitoneal Melatonin on Caustic Sclerosing Cholangitis Due to Scolicidal Solution in a Rat Model
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Effects of Intraperitoneal Melatonin on Caustic Sclerosing Cholangitis Due to Scolicidal Solution in a Rat Model

机译：腹腔内褪黑激素对大鼠模型溶液致死性硬化性胆管炎的影响

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BACKGROUND: Hydatid disease is a worldwide health problem. Treatment is surgical or percutaneous, using scolicidal agents. Caustic sclerosing cholangitis might develop after the contact of scolicidal agents with the biliary ducts. Melatonin, an antioxidant, anti-inflammatory, and anticarcinogenic agent, might be used in the treatment of caustic sclerosing cholangitis due to its possible preventive effects on fibrosis and cell damage.OBJECTIVE: The aim of the study was to investigate the effects of melatonin on an experimentally developed caustic sclerosing cholangitis with scolicidal solution (formalin) in a rat model.METHODS: Forty female Sprague-Dawley rats aged 11 to 13 weeks and weighing 250 +- 30 g were randomly assigned to 1 of 4 groups of 10: formalin 5% at 0.5 mL/d + melatonin placebo; formalin placebo + intraperitoneal melatonin 10 mg/kg/d; formalin 5% at 0.5 mL/d + melatonin 10 mg/kg/d; and formalin placebo and melatonin placebo (control). Hepatobiliary function was assessed using dynamic scintigraphy with technetium-99m-mebrofenin on study day 60. The histology of the liver and biliary duct specimens was examined on study day 60. In each group, histopathologic alterations were scored as absent, slight, mild, or severe.RESULTS: Mean severity scores for parenchymal necrosis in the liver (P < 0.01), portal fibrosis (P < 0.01), biliary duct proliferation (P < 0.001), cholangitis/ pericholangitis (P < 0.01), hyperemia in the biliary ducts (P < 0.01), and fibrosis (P < 0.01) were significantly lower in rats treated with formalin + melatonin compared with those treated with formalin alone. No significant differences were observed between the 3 treatment groups with respect to t_(1/2), a parameter used to assess the secretion function of the hepatocytes. However, the t_(1/2) was significantly longer in the treatment groups compared with controls (P < 0.001).CONCLUSION: In this experimental study in a rat model of caustic sclerosing cholangitis, the histopathologic and scintigraphic findings suggested that melatonin is effec-tive in attenuating the damage caused by scolicidal agents on the liver and biliary ducts.
机译：背景：包虫病是全球性的健康问题。使用杀伤剂可以通过外科手术或经皮治疗。杀卵剂与胆管接触后，可能会出现腐蚀性硬化性胆管炎。褪黑素是一种抗氧化剂，抗炎剂和抗癌剂，因其可能对纤维化和细胞损伤具有预防作用，因此可能被用于治疗腐蚀性硬化性胆管炎。目的：研究目的是研究褪黑素对肝硬化的作用。实验方法：在大鼠模型中用杀伤性溶液（福尔马林）进行实验性苛性硬化性胆管炎。方法：将40只雌性Sprague-Dawley大鼠（年龄11至13周，体重250±30 g）随机分为4组，每组10组，其中1组为福尔马林5 0.5 mL / d +褪黑素安慰剂时的％;福尔马林安慰剂+腹膜内褪黑激素10 mg / kg / d; 5％福尔马林，0.5 mL / d +褪黑激素10 mg / kg / d;以及福尔马林安慰剂和褪黑激素安慰剂（对照）。在研究第60天时使用动态闪烁显影术和99m-甲基溴芬太尼评估肝胆功能。在研究第60天时检查肝和胆管标本的组织学。在每组中，将组织病理学改变记为无，轻度，轻度或结果：肝脏实质坏死的平均严重程度评分（P <0.01），门静脉纤维化（P <0.01），胆管增生（P <0.001），胆管炎/胆管炎（P <0.01），胆管充血与仅用福尔马林治疗的大鼠相比，用福尔马林+褪黑素治疗的大鼠的纤维化（P <0.01）和纤维化（P <0.01）显着降低。关于t_（1/2），这是用于评估肝细胞分泌功能的参数，在三个治疗组之间未观察到显着差异。然而，与对照组相比，治疗组的t_（1/2）明显更长（P <0.001）。结论：在此实验性苛性硬化性胆管炎大鼠模型中，组织病理学和闪烁显像结果表明褪黑激素是有效的减轻由杀卵剂对肝脏和胆管造成的损害。

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