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首页> 外文期刊>Current therapeutic research, clinical and experimental. >The effects of Different Concentrations and Equivalent Volumes of Levobupivacaine in Epidural Anesthesia
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The effects of Different Concentrations and Equivalent Volumes of Levobupivacaine in Epidural Anesthesia

机译：左旋布比卡因不同浓度和当量对硬膜外麻醉的影响

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BACKGROUND: Levobupivacaine, the S(-) isomer of bupivacaine, is less cardio-toxic than racemic bupivacaine. Previous studies have examined different concentrations of levobupivacaine in similar ways.OBJECTIVES: This prospective, randomized, double-blind study was designed to determine the clinical efficacy and hemodynamic effects of different concentrations and equivalent volumes of levobupivacaine in epidural anesthesia. To our knowledge, this is the first study to evaluate the effects of concentration lower than 0.5% levobupivacaine.METHODS: Forty adult patients with an American Society of Anesthesiology (ASA) I-III physical status undergoing transurethral endoscopic surgery were randomly divided into 2 groups to receive either 10 mL of isobaric levobupivacaine (0.5% + 5 mL 0.9% saline [group 1; n - 20]) or 10 mL of isobaric levobupivacaine (0.75% + 5 mL saline 0.9% saline [group 2; n = 20]) for epidural anesthesia. An observer blinded to group division evaluated the time of onset, maximum level, and time to 2-segment regression of sensory block.RESUUTS: There were no differences between the 2 groups in terms of hemodynamic parameters and time of onset of the sensory block. There were significant differences, however, between the 2 groups in the maximum level of the sensory block (group 1, T9; group 2, T8; P = 0.010) and the time to 2-segment regression of sensory block (group 1, 46.35 minutes; group 2, 62.94 minutes; P - 0.013).CONCLUSION: This study indicated that 10 mL of 0.5% levobupivacaine plus 5 mL of 0.9% saline is a suitable solution for use in epidural anesthesia because it produces a block clinically comparable to that of 10 mL of 0.75% levobupivacaine plus 5 mL of 0.9% saline for transurethral resection of prostate surgery.
机译：背景：左旋布比卡因是布比卡因的S（-）异构体，其心脏毒性比外消旋布比卡因低。以前的研究以相似的方式检查了不同浓度的左旋布比卡因。目的：这项前瞻性，随机，双盲研究旨在确定硬膜外麻醉中不同浓度和当量的左旋布比卡因的临床疗效和血液动力学效应。据我们所知，这是第一个评估浓度低于0.5％左旋布比卡因的影响的研究。方法：将40名接受美国麻醉学会（ASA）I-III身体状况的成人患者接受经尿道内镜手术，随机分为两组接受10 mL等压左旋布比卡因（0.5％+ 5 mL 0.9％盐水[组1; n-20]）或10 mL等压左旋布比卡因（0.75％+ 5 mL盐水0.9％盐水[组2; n = 20] ）用于硬膜外麻醉。一位不愿进行分组划分的观察者评估了感觉障碍的发作时间，最大水平以及两段消退的时间。结果：两组在血流动力学参数和感觉障碍发作时间方面没有差异。但是，两组之间在感觉障碍的最大水平（第1组，T9;第2组，T8; P = 0.010）和感觉障碍的2段回归时间（第1组，46.35）之间存在显着差异。分钟;第2组，每分钟62.94分钟; P-0.013）。结论：这项研究表明，硬膜外麻醉的10 mL 0.5％左旋布比卡因加5 mL 0.9％生理盐水是一种合适的溶液，因为它在临床上可与之媲美10 mL的0.75％左旋布比卡因加5 mL的0.9％生理盐水用于经尿道前列腺切除术。

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